New insights into iNKT cells and their roles in liver diseases

X Gu, Q Chu, X Ma, J Wang, C Chen, J Guan… - Frontiers in …, 2022 - frontiersin.org
Natural killer T cells (NKTs) are an important part of the immune system. Since their
discovery in the 1990s, researchers have gained deeper insights into the physiology and …

Leishmaniasis: immune cells crosstalk in macrophage polarization

FS Almeida, SER Vanderley, FC Comberlang… - Tropical Medicine and …, 2023 - mdpi.com
Leishmaniasis is a complex infectious parasitic disease caused by protozoa of the genus
Leishmania, belonging to a group of neglected tropical diseases. It establishes significant …

Type I natural killer T cells as key regulators of the immune response to infectious diseases

NMS Gálvez, K Bohmwald, GA Pacheco… - Clinical Microbiology …, 2021 - Am Soc Microbiol
The immune system must work in an orchestrated way to achieve an optimal response upon
detection of antigens. The cells comprising the immune response are traditionally divided …

Exploring the paradox of defense between host and Leishmania parasite

D Kumari, K Singh - International immunopharmacology, 2022 - Elsevier
Leishmaniasis, a neglected tropical disease, still remains a global concern for the
healthcare sector. The primary causative agents of the disease comprise diverse …

[HTML][HTML] Functional aspects of T cell diversity in visceral leishmaniasis

JJ Jawed, S Dutta, S Majumdar - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Co-ordination between innate and adaptive immunity is a foremost crucial immunological
interactions. The interaction is beneficial for the survival of the host against infectious agent …

[HTML][HTML] Chemokines in Leishmaniasis: Map of cell movements highlights the landscape of infection and pathogenesis

FF de Araújo, MF Costa-Silva, AAS Pereira, FD Rêgo… - Cytokine, 2021 - Elsevier
Pathogen interactions with the host immune response components are critical for
establishing protective immunity and pathological responses against Leishmania parasites …

Foxp3+ Tregs from Langerhans cell histiocytosis lesions co-express CD56 and have a definitively regulatory capacity

J Mitchell, J Kelly, E Kvedaraite… - Clinical …, 2020 - Elsevier
Langerhans cell histiocytosis (LCH) lesions contain myeloid lineage 'LCH'cells. Regulatory
T cells (Tregs) are also enriched within lesions, although their role in LCH pathogenesis is …

C–C chemokine receptor 5 is essential for conventional NK cell trafficking and liver injury in a murine hepatitis virus-induced fulminant hepatic failure model

YH Liu, L Zhu, ZW Zhang, TT Liu, QY Cheng… - Journal of Translational …, 2023 - Springer
Background Previous studies have demonstrated that natural killer (NK) cells migrated into
the liver from peripheral organs and exerted cytotoxic effects on hepatocytes in virus …

Visceral Leishmaniasis in Immunocompetent Hosts in Brescia: A Case Series and Analysis of Cytokine Cascade

A Mulè, V Crosato, DB Kuhns, L Lorenzi, C Chirico… - Microorganisms, 2024 - mdpi.com
Visceral leishmaniasis (VL) is a parasitic zoonosis caused by Leishmania spp. that usually
manifests itself in immunocompromised subjects. It is a rare and neglected disease, and it is …

Chemokines Signature and T Cell Dynamics in Leishmaniasis: Molecular insight and therapeutic application

S Upadhyay, S Kumar, VK Singh, R Tiwari… - Expert Reviews in …, 2024 - cambridge.org
Leishmaniasis, caused by obligate intracellular Leishmania parasites, poses a significant
global 19 health burden. The control of Leishmania infection relies on an effective T cell …