MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease
Fatty liver associated with metabolic dysfunction is common, affects a quarter of the
population, and has no approved drug therapy. Although pharmacotherapies are in …
population, and has no approved drug therapy. Although pharmacotherapies are in …
Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention
NAFLD is one of the most important causes of liver disease worldwide and will probably
emerge as the leading cause of end-stage liver disease in the coming decades, with the …
emerge as the leading cause of end-stage liver disease in the coming decades, with the …
Cause, pathogenesis, and treatment of nonalcoholic steatohepatitis
AM Diehl, C Day - New England Journal of Medicine, 2017 - Mass Medical Soc
Nonalcoholic steatohepatitis is a major cause of cirrhosis and liver cancer. It is associated
with visceral adiposity and the metabolic syndrome and is nearly as common as type 2 …
with visceral adiposity and the metabolic syndrome and is nearly as common as type 2 …
Genetics and epigenetics of NAFLD and NASH: Clinical impact
Non-alcoholic fatty liver disease (NAFLD) is now recognised as the most common liver
disease worldwide. It encompasses a broad spectrum of conditions, from simple steatosis …
disease worldwide. It encompasses a broad spectrum of conditions, from simple steatosis …
Hepatic stellate cells as key target in liver fibrosis
T Higashi, SL Friedman, Y Hoshida - Advanced drug delivery reviews, 2017 - Elsevier
Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more
than one million deaths annually via development of cirrhosis, although no antifibrotic …
than one million deaths annually via development of cirrhosis, although no antifibrotic …
Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications
R Weiskirchen, S Weiskirchen, F Tacke - Molecular aspects of medicine, 2019 - Elsevier
Fibrosis denotes excessive scarring, which exceeds the normal wound healing response to
injury in many tissues. Although the extracellular matrix deposition appears unstructured …
injury in many tissues. Although the extracellular matrix deposition appears unstructured …
Noninvasive biomarkers in NAFLD and NASH—current progress and future promise
VWS Wong, LA Adams, V de Lédinghen… - Nature reviews …, 2018 - nature.com
Nonalcoholic fatty liver disease (NAFLD) affects 25% of the global adult population and is
the most common chronic liver disease worldwide. Nonalcoholic steatohepatitis (NASH) is …
the most common chronic liver disease worldwide. Nonalcoholic steatohepatitis (NASH) is …
Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases
Key physiological functions of the liver, including glucose and lipid metabolism, become
disturbed in the setting of non-alcoholic fatty liver disease (NAFLD) and may be associated …
disturbed in the setting of non-alcoholic fatty liver disease (NAFLD) and may be associated …
Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers
E Vilar-Gomez, N Chalasani - Journal of hepatology, 2018 - Elsevier
The correct identification of patients at increased risk of non-alcoholic steatohepatitis
(NASH) and advanced fibrosis is a critical step in the assessment of non-alcoholic fatty liver …
(NASH) and advanced fibrosis is a critical step in the assessment of non-alcoholic fatty liver …
Lean NAFLD: a distinct entity shaped by differential metabolic adaptation
Conclusions This study demonstrates that E. multilocularis can induce T‐cell exhaustion
through inhibitory receptor TIGIT, and that blocking this checkpoint may reverse the …
through inhibitory receptor TIGIT, and that blocking this checkpoint may reverse the …