Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer's disease

D Kaur, V Sharma, R Deshmukh - Inflammopharmacology, 2019 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease that is of high importance to the
neuroscience world, yet the complex pathogenicity is not fully understood. Inflammation is …

Glial cells in Alzheimer's disease: From neuropathological changes to therapeutic implications

MS Uddin, LW Lim - Ageing research reviews, 2022 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder that usually develops slowly and
progressively worsens over time. Although there has been increasing research interest in …

Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis)

E Gaggelli, H Kozlowski, D Valensin… - Chemical …, 2006 - ACS Publications
Copper is too redox active to exist in an unbound form in the cell without causing oxidative
damage: an upper limit of 10-18 M for the free concentration of Cu (II) in unstressed cells has …

The present and future of pharmacotherapy of Alzheimer's disease: A comprehensive review

A Anand, AA Patience, N Sharma, N Khurana - European journal of …, 2017 - Elsevier
Alzheimer's disease (AD) is a generalized term used for the loss in memory and other
intellectual abilities on levels serious enough to interfere with daily life. It accounts for 60 …

On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis

RT Bartus - Experimental neurology, 2000 - Elsevier
Life's Journey If life is indeed a journey, then poetry must be the map that reveals all its
topographic possibilities… while science is the compass that keeps us from getting lost.—RT …

The significance of the cholinergic system in the brain during aging and in Alzheimer's disease

R Schliebs, T Arendt - Journal of neural transmission, 2006 - Springer
Acetylcholine is widely distributed in the nervous system and has been implicated to play a
critical role in cerebral cortical development, cortical activity, controlling cerebral blood flow …

Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection

M Singh, M Kaur, H Kukreja, R Chugh, O Silakari… - European journal of …, 2013 - Elsevier
Acetylcholinesterase is a member of the α/β hydrolase protein super family, with a significant
role in acetylcholine-mediated neurotransmission. Research in the modulators of AChEs …

A structural motif of acetylcholinesterase that promotes amyloid β-peptide fibril formation

GV De Ferrari, MA Canales, I Shin, LM Weiner… - Biochemistry, 2001 - ACS Publications
Acetylcholinesterase (AChE) has been found to be associated with the core of senile
plaques. We have shown that AChE interacts with the amyloid β-peptide (Aβ) and promotes …

Target enzyme in Alzheimer's disease: Acetylcholinesterase inhibitors

M Saxena, R Dubey - Current topics in medicinal chemistry, 2019 - ingentaconnect.com
Alzheimer's Disease (AD), affecting a large population worldwide is characterized by the
loss of memory and learning ability in the old population. The enzyme Acetylcholinesterase …

The multifactorial nature of Alzheimer's disease for developing potential therapeutics

M Carmo Carreiras, E Mendes… - Current topics in …, 2013 - ingentaconnect.com
Alzheimerβs disease (AD) is a multifactorial neurodegenerative disorder with several target
proteins contributing to its aetiology. Pathological, genetic, biochemical, and modeling …