Albeit essential for perpetuation of species, reproduction is an energy-demanding function
that can be adjusted to body metabolic status. Reproductive maturation and function can be …

The blood–brain barrier (BBB) tightly controls the molecular exchange between the brain
parenchyma and blood. Accumulated evidence from transgenic animal Alzheimer's disease …

Unconjugated hyperbilirubinemia is a common condition in the first week of postnatal life.
Although generally harmless, some neonates may develop very high levels of unconjugated …

The chemical signalling molecule nitric oxide (NO), which freely diffuses through aqueous
and lipid environments, subserves an array of functions in the mammalian central nervous …

The transition to puberty and adult fertility both require a minimum level of energy
availability. The adipocyte-derived hormone leptin signals the long-term status of peripheral …

The discoveries of novel functional adaptations of the hypothalamus and anterior pituitary
gland for physiological regulation have transformed our understanding of their interaction …

Reproduction is controlled in the brain by a neural network that drives the secretion of
gonadotropin-releasing hormone (GnRH). Various permissive homeostatic signals must be …

Background The maturation of the hypothalamic-pituitary-gonadal (HPG) axis is crucial for
the establishment of reproductive function. In female mice, neuronal nitric oxide synthase …

Highly sophisticated and synchronized interactions of various cells and hormonal signals
are required to make organisms competent for reproduction. GnRH neurons act as a …

Apart from its well-known role in regulating endothelial function, in mammals, nitric oxide
(NO) is an important signaling molecule involved in many processes, regulating different …