[HTML][HTML] The 2021 WHO classification of tumors of the thymus and mediastinum: what is new in thymic epithelial, germ cell, and mesenchymal tumors?

A Marx, JKC Chan, L Chalabreysse, S Dacic… - Journal of Thoracic …, 2022 - Elsevier
This overview of the fifth edition of the WHO classification of thymic epithelial tumors
(including thymomas, thymic carcinomas, and thymic neuroendocrine tumors [NETs]) …

Thymic carcinomas—a concise multidisciplinary update on recent developments from the Thymic Carcinoma Working Group of the International Thymic Malignancy …

AC Roden, U Ahmad, G Cardillo, N Girard… - Journal of Thoracic …, 2022 - Elsevier
Thymic carcinomas are rare malignancies that in general arise in the prevascular (anterior)
mediastinum. These tumors are usually invasive, often present at advanced stages, and …

Phase II study of everolimus in patients with thymoma and thymic carcinoma previously treated with cisplatin-based chemotherapy

PA Zucali, T De Pas, G Palmieri, A Favaretto… - Journal of Clinical …, 2018 - ascopubs.org
Purpose No effective salvage treatments are available for patients with advanced/recurrent
thymoma (T) or thymic carcinoma (TC) who have progressed after platinum-based …

Thymic epithelial tumors: From biology to treatment

F Conforti, L Pala, G Giaccone, T De Pas - Cancer treatment reviews, 2020 - Elsevier
In the last few years, meaningful advances have been made in the knowledge of the biology
of Thymic Epithelial Tumors (TETs). Data available suggest that in most cases, the different …

Comprehensive genomic profiling of 274 thymic epithelial tumors unveils oncogenic pathways and predictive biomarkers

N Girard, C Basse, A Schrock, S Ramkissoon… - The …, 2022 - academic.oup.com
Background Thymic malignancies represent a heterogeneous group of rare thoracic
cancers, which are classified according to the World Health Organization histopathologic …

A knock-in mouse model of thymoma with the GTF2I L424H mutation

Y He, IK Kim, J Bian, A Polyzos… - Journal of Thoracic …, 2022 - Elsevier
Introduction The pathogenesis of thymic epithelial tumors remains largely unknown. We
previously identified GTF2I L424H as the most frequently recurrent mutation in thymic …

[HTML][HTML] Checkpoint kinase 1 inhibition enhances cisplatin cytotoxicity and overcomes cisplatin resistance in SCLC by promoting mitotic cell death

WH Hsu, X Zhao, J Zhu, IK Kim, G Rao… - Journal of Thoracic …, 2019 - Elsevier
Introduction Platinum-based chemotherapy remains the standard treatment for patients with
SCLC, but the benefit of the treatment is often hampered by rapid development of drug …

STYLE (NCT03449173): a phase 2 trial of sunitinib in patients with type B3 thymoma or thymic carcinoma in second and further lines

C Proto, S Manglaviti, GL Russo, M Musca… - Journal of Thoracic …, 2023 - Elsevier
Introduction Thymic malignancies are rare tumors with few therapeutic options. The STYLE
trial was aimed to evaluate activity and safety of sunitinib in advanced or recurrent type B3 …

Unraveling molecular networks in thymic epithelial tumors: deciphering the unique signatures

X Zhang, P Zhang, A Cong, Y Feng, H Chi… - Frontiers in …, 2023 - frontiersin.org
Thymic epithelial tumors (TETs) are a rare and diverse group of neoplasms characterized by
distinct molecular signatures. This review delves into the complex molecular networks of …

An overview on molecular characterization of thymic tumors: old and new targets for clinical advances

V Tateo, L Manuzzi, C Parisi, A De Giglio, D Campana… - Pharmaceuticals, 2021 - mdpi.com
Thymic tumors are a group of rare mediastinal malignancies that include three different
histological subtypes with completely different clinical behavior: the thymic carcinomas, the …