In the two decades since the introduction of the “click chemistry” concept, the toolbox of “click
reactions” has continually expanded, enabling chemists, materials scientists, and biologists …

Gene editing using clustered regularly interspaced short palindromic repeat/CRISPR-
associated proteins (CRISPR/Cas) has revolutionized biotechnology and provides genetic …

CRISPR diagnostics based on nucleic acid amplification faces barriers to its commercial
use, such as contamination risks and insufficient sensitivity. Here, we propose a robust …

The clustered regularly interspaced short palindromic repeats (CRISPR) system is a
promising platform for nucleic acid detection. Regulating the CRISPR reaction would be …

As a golden partner of recombinase polymerase amplification (RPA), CRISPR/Cas12a has
been proven to solve the false-positive problem caused by nonspecific amplification …

The precision and therapeutic potential of CRISPR/Cas9 genome editing are greatly
challenged by the less control over Cas9-mediated DNA cleavage. Herein, we introduce a …

The CRISPR/Cas system is one of the most powerful tools for gene editing. However,
approaches for precise control of genome editing and regulatory events are still desirable …

The discovery and applications of clustered regularly interspaced short palindromic repeat
(CRISPR) systems have revolutionized our ability to track and manipulate specific nucleic …

Rectifying the aberrant microenvironment of a disease through maintenance of redox
homeostasis has emerged as a promising perspective with significant therapeutic potential …

CRISPR-Cas9 is quickly revolutionizing the way we approach gene therapy. CRISPR-Cas9
is a complexed, two-component system using a short guide RNA (gRNA) sequence to direct …