The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing
malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating …

Targeted covalent inhibitors have gained widespread attention in drug discovery as a
validated method to circumvent acquired resistance in oncology. This strategy exploits small …

Hsp70 proteins are key to maintaining intracellular protein homeostasis. To carry out this
task, they employ a large number of cochaperones and adapter proteins. Here, we review …

Deazapurine (pyrrolo [2, 3‐d] pyrimidine) nucleosides are important analogues of biogenic
purine nucleosides with diverse biological activities. Replacement of the N7 atom with a …

Alzheimer's disease is a neurodegenerative disorder in which misfolding and aggregation of
pathologically modified Tau is critical for neuronal dysfunction and degeneration. The two …

The covalent inhibition mechanism of action, which overcomes competition with high-affinity,
high-abundance substrates of challenging protein targets, can deliver effective chemical …

Most molecular chaperones belonging to heat shock protein (HSP) families are known to
protect cancer cells from pathologic, environmental and pharmacological stress factors and …

The stress‐inducible molecular chaperone, HSP72, is an important therapeutic target in
oncology, but inhibiting this protein with small molecules has proven particularly …

This personal perspective focuses on small-molecule inhibitors of proteostasis networks in
cancer—specifically the discovery and development of chemical probes and drugs acting on …

The heat shock protein 70s (HSP70s) are molecular chaperones implicated in many cancers
and of significant interest as targets for novel cancer therapies. Several HSP70 inhibitors …