BACKGROUND Primary ovarian insufficiency (POI) is characterized by marked
heterogeneity, but with a significant genetic contribution. Identifying exact causative genes …

Primary ovarian insufficiency is one of the main causes of female infertility owing to an
abnormal ovarian reserve. Its relevance has increased in more recent years due to the fact …

Classic galactosemia is an inborn error of the metabolism with devastating consequences.
Newborn screening has been successful in markedly reducing the acute neonatal symptoms …

Several causes for primary ovarian insufficiency (POI) have been described, including
iatrogenic and environmental factor, viral infections, chronic disease as well as genetic …

Significant progress has been made in several fields of medicine towards personalizing
treatment recommendations based on individual patient genotype. As the number of clinical …

Premature ovarian failure (POF), also termed primary ovarian insufficiency, is a common
disorder in women of reproductive age. This discussion focuses predominately on single …

Hypogonadotropic and hypergonadotropic forms of hypogonadism exist. In the
hypogonadotropic phenotype, functional etiology originates from GnRH neurons in the …

Amaç: Kromozom anomalileri, prematür ovaryen yetmezliğin önemli nedenlerinden birisidir
ve reprodüktif yönetimde kromozom analizinin önemi doğrulanmıştır. Sayısal ve yapısal …

Primary ovarian insufficiency (POI) is a medical condition where ovarian function stops
prematurely, typically before the age of 40. This condition leads to infertility and produces …

Genome-wide association study (GWAS) has revolutionized the identification of causal
genetic variants and the subsequent characterization of complex genetic traits. GWAS is a …