Hyperuricemia (HUA) has attained a considerable global health concern, related to the
development of other metabolic syndromes. Xanthine oxidase (XO), the main enzyme that …

Hyperuricemia (HUA), or elevated uric acid in the blood, has become more prevalent in
recent years. Polyphenols, which are known to have good inhibitory activity on xanthine …

Carboxylated chalcones and other related flavonoids were synthesized and evaluated as
inhibitors of xanthine oxidase, which is a known target for synthetic and herbal drugs used …

Hyperuricemia, a disease characterized by elevation of serum uric acid level beyond 6
mg/dL. This elevation led to appearance of symptoms from joint pain to gout and from gout to …

Considerable ingenuity has been shown in the recent years in the discovery of novel
xanthine oxidase (XO) inhibitors that fall outside the purine scaffold. The triazole nucleus …

Background Hyperuricemia (HUA) is a metabolic disease characterized by a high level of
uric acid (UA). The extensive historical application of traditional Chinese medicine (TCM) …

Febuxostat (FEB) is the first non-purine xanthine oxidase inhibitor (XOI) used for the
treatment of hyperuricemia and gout. The oxidative stress induced by reactive oxygen …

Xanthine oxidase (XO) is an important enzyme that catalyzes the oxidation of hypoxanthine
to xanthine and xanthine to uric acid in the catabolism of purines in humans. This makes XO …

In silico approaches have been employed to design a new series of benzimidazole-
containing sulphonamide derivatives and qualified compounds have been synthesized to …

Hyperuricemia is characterized by higher-than-normal levels of uric acid in the bloodstream.
This condition can increase the likelihood of developing gout, a form of arthritis triggered by …