[HTML][HTML] A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironment

JM Kastenschmidt, JG Schroers-Martin, BJ Sworder… - Cell Stem Cell, 2024 - cell.com
Heterogeneity in the tumor microenvironment (TME) of follicular lymphomas (FLs) can affect
clinical outcomes. Current immunotherapeutic strategies, including antibody-and cell-based …

Glucose metabolism in B cell malignancies: a focus on glycolysis branching pathways

H Simon‐Molas, R Del Prete… - Molecular Oncology, 2024 - Wiley Online Library
Glucose catabolism, one of the essential pathways sustaining cellular bioenergetics, has
been widely studied in the context of tumors. Nevertheless, the function of various branches …

Emerging Strategies in 3D Culture Models for Hematological Cancers

D Barozzi, C Scielzo - HemaSphere, 2023 - journals.lww.com
In vitro cell cultures are fundamental and necessary tools in cancer research and
personalized drug discovery. Currently, most cells are cultured using two-dimensional (2D) …

Development of patient-derived lymphomoids with preserved tumor architecture for lymphoma therapy screening

A Santamaria-Martínez, J Epiney, D Srivastava… - Nature …, 2024 - nature.com
The efficacy of anti-cancer therapies depends on the genomic composition of the tumor, its
microenvironment, spatial organization, and intra-tumor heterogeneity. B-cell lymphomas …

Targeting CERS6-AS1/FGFR1 axis as synthetic vulnerability to constrain stromal cells supported proliferation in Mantle cell lymphoma

U Jindal, M Mamgain, UK Nath, I Sharma, B Pant… - Leukemia, 2024 - nature.com
The interaction between stromal and tumor cells in tumor microenvironment is a crucial
factor in Mantle cell lymphoma (MCL) progression and therapy resistance. We have …

Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target

C Dobaño-López, JG Valero, F Araujo-Ayala… - Blood Cancer …, 2024 - nature.com
Follicular lymphoma (FL), the most common indolent non-Hodgkin lymphoma, constitutes a
paradigm of immune tumor microenvironment (TME) contribution to disease onset …

Empowering macrophages: the cancer fighters within the tumour microenvironment in mantle cell lymphoma

P Nylund, A Nikkarinen, S Ek, I Glimelius - Frontiers in Immunology, 2024 - frontiersin.org
In Mantle Cell Lymphoma (MCL), the role of macrophages within the tumour
microenvironment (TME) has recently gained attention due to their impact on prognosis and …

Spheroid culture to select theoretical therapeutic drugs in intravascular large B‐cell lymphoma

M Takai, K Shimada, K Furukawa, Y Yamaga… - Cancer …, 2024 - Wiley Online Library
Intravascular large B‐cell lymphoma (IVLBCL) is a rare type of extranodal large B‐cell
lymphoma that is characterized by the proliferation of lymphoma cells in the lumina of small …

TIGIT: Will it be the next star therapeutic target like PD-1 in hematological malignancies?

Y Liu, W Liu, T Wu - Critical Reviews in Oncology/Hematology, 2024 - Elsevier
Research on the mechanism and application of checkpoint inhibitory receptors in
hematologic diseases has progressed rapidly. However, in the treatment of relapserefractory …

An overview of immunotoxicity in drug discovery and development

RM Nandre, PS Terse - Toxicology Letters, 2024 - Elsevier
The immune system is one of the common targets of drugs' toxicity (Immunotoxicity) and/or
efficacy (Immunotherapy). Immunotoxicity leads to adverse effects on human health, which …