Epigenetic modifications work in concert with genetic mechanisms to regulate transcriptional
activity in normal tissues and are often dysregulated in disease. Although they are …

Cancer is one of the leading diseases, causing deaths worldwide. Nearly 10 million deaths
were reported in 2020 due to cancer alone. Several factors are involved in cancer …

The evolutionary history of tumor cell populations can be reconstructed from patterns of
genetic alterations. In contrast to stable genetic events, epigenetic states are reversible and …

Cellular processes requiring access to the DNA genome are regulated by an overlay of
epigenetic modifications, including histone modification and chromatin remodeling. Similar …

Exosomes, microvesicles, and other extracellular vesicles are released by many cell types,
including cancer cells and cancer‐related immune cells. Extracellular vesicles can directly …

The O 6-methylguanine-DNA methyltransferase (MGMT) gene is located at chromosome
10q26 and codes for a DNA repair enzyme that—if active—can counteract the effects of …

Neural stem cells (NSCs) undergo self-renewal and generate neurons and glial cells under
the influence of specific signals from surrounding environments. Glioblastoma multiforme …

Cytosine DNA methylation, covalent histone modifications, and RNA-mediated gene
regulation are the major aspects of epigenetic regulation. Natural antisense transcripts …

Penile carcinoma is a rare, male cancer. Although the incidence of penile carcinoma is very
low in Western countries, in some countries, the incidence is significantly greater, with penile …

Artificial Intelligence (AI) is the subject of a challenge and attention in the field of oncology
and raises many promises for preventive diagnosis, but also fears, some of which are based …