Alzheimer's disease (AD), certainly the most widespread proteinopathy, has as classical
neuropathological hallmarks, two groups of protein aggregates: senile plaques and …

NLRP3 inflammasome activation is a highly regulated process for controlling secretion of the
potent inflammatory cytokines IL-1β and IL-18 that are essential during bacterial infection …

Strong evidence suggests a correlation between degeneration and mitochondrial deficiency.
Typical cases of degeneration can be observed in physiological phenomena (ie, ageing) as …

An increasing number of the population all around the world suffer from age-associated
neurodegenerative diseases including Parkinson's disease (PD). This disorder presents …

Mitochondria, composed of two membranes, play a key role in energy production in
eukaryotic cells. The main function of the inner membrane is oxidative phosphorylation …

Voltage-dependent anion channels (VDAC1-3) of the outer mitochondrial membrane are a
family of pore-forming β-barrel proteins that carry out controlled “filtration” of small molecules …

Ion channels exhibit gating behavior, fluctuating between open and closed states, with the
transmembrane voltage serving as one of the essential regulators of this process. Voltage …

The voltage-dependent anion channel (VDAC) is the primary regulating pathway of water-
soluble metabolites and ions across the mitochondrial outer membrane. The VDAC was …

ABSTRACT Serine-129 phosphorylated α-synuclein (p-α-syn), accounting for nearly 90% of
α-synuclein (α-syn) found in Lewy bodies (LBs), is linked to the pathogenesis of Parkinson's …

VBIT-4 is a new inhibitor of the oligomerization of VDAC proteins of the outer mitochondrial
membrane preventing the development of oxidative stress, mitochondrial dysfunction, and …