On the expansion of biological functions of lytic polysaccharide monooxygenases

TM Vandhana, JL Reyre, D Sushmaa… - New …, 2022 - Wiley Online Library
Lytic polysaccharide monooxygenases (LPMOs) constitute an enigmatic class of enzymes,
the discovery of which has opened up a new arena of riveting research. LPMOs can …

A critical assessment on scalable technologies using high solids loadings in lignocellulose biorefinery: challenges and solutions

R Arora, P Singh, PK Sarangi, S Kumar… - Critical reviews in …, 2024 - Taylor & Francis
The pretreatment and the enzymatic saccharification are the key steps in the extraction of
fermentable sugars for further valorization of lignocellulosic biomass (LCB) to biofuels and …

Harnessing microbial wealth for lignocellulose biomass valorization through secretomics: a review

S Sethupathy, GM Morales, Y Li, Y Wang, J Jiang… - Biotechnology for …, 2021 - Springer
The recalcitrance of lignocellulosic biomass is a major constraint to its high-value use at
industrial scale. In nature, microbes play a crucial role in biomass degradation, nutrient …

Lytic polysaccharide monooxygenase (LPMO)-derived saccharification of lignocellulosic biomass

M Moon, JP Lee, GW Park, JS Lee, HJ Park… - Bioresource Technology, 2022 - Elsevier
Given that traditional biorefineries have been based on microbial fermentation to produce
useful fuels, materials, and chemicals as metabolites, saccharification is an important step to …

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2019–2020

DJ Harvey - Mass Spectrometry Reviews, 2023 - Wiley Online Library
This review is the tenth update of the original article published in 1999 on the application of
matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of …

Molecular mechanism of substrate oxidation in lytic polysaccharide monooxygenases: insight from theoretical investigations

MM Hagemann, ED Hedegård - Chemistry–A European …, 2023 - Wiley Online Library
Lytic polysaccharide monooxygenases (LPMOs) are copper enzymes that today comprise a
large enzyme superfamily, grouped into the distinct members AA9–AA17 (with AA12 …

On the roles of AA15 lytic polysaccharide monooxygenases derived from the termite Coptotermes gestroi

JPLF Cairo, D Cannella, LC Oliveira… - Journal of inorganic …, 2021 - Elsevier
Lytic polysaccharide monooxygenases (LPMOs) are copper-dependent enzymes which
catalyze the oxidative cleavage of polysaccharides. LPMOs belonging to family 15 in the …

pH-mediated manipulation of the histidine brace in LPMOs and generation of a tri-anionic variant, investigated by EPR, ENDOR, ESEEM and HYSCORE spectroscopy

J Haak, O Golten, M Sørlie, VGH Eijsink… - Chemical Science, 2025 - pubs.rsc.org
Lytic Polysaccharide Monooxygenases (LPMOs) catalyze the oxidative depolymerization of
polysaccharides at a monocopper active site, that is coordinated by the so-called histidine …

Mutational dissection of a hole hopping route in a lytic polysaccharide monooxygenase (LPMO)

I Ayuso-Fernández, TZ Emrich-Mills, J Haak… - Nature …, 2024 - nature.com
Oxidoreductases have evolved tyrosine/tryptophan pathways that channel highly oxidizing
holes away from the active site to avoid damage. Here we dissect such a pathway in a …

Decoding the Ambiguous Electron Paramagnetic Resonance Signals in the Lytic Polysaccharide Monooxygenase from Photorhabdus luminescens

RJ Gómez-Piñeiro, M Drosou, S Bertaina… - Inorganic …, 2022 - ACS Publications
Understanding the structure and function of lytic polysaccharide monooxygenases (LPMOs),
copper enzymes that degrade recalcitrant polysaccharides, requires the reliable atomistic …