Hepatitis B virus (HBV) is one of the seven known human oncogenic viruses and has
adapted to coexist with a single host for prolonged periods, requiring continuous …

As a small DNA virus, hepatitis B virus (HBV) plays a pivotal role in the development of
various liver diseases, including hepatitis, cirrhosis, and liver cancer. Among the molecules …

Abstract microRNAs (miRNAs) play essential roles in progression of hepatocellular
carcinoma (HCC). However, the roles of miR-196a and miR-196b as well as mechanism in …

It is not clear how hepatitis B virus (HBV) modulates host immunity during chronic infection.
In addition to the key mediators of inflammatory response in viral infection, monocytes also …

Nod-like receptor protein 3 (NLRP3), absent in melanoma 2 (AIM2), and interferon gamma
inducible protein 16 (IFI16) are innate immune sensors for intracellular microbes, which can …

Background & Aims HBsAg loss is only observed in a small proportion of patients with
chronic hepatitis B (CHB) who undergo interferon treatment. Investigating the host factors …

Increasing evidence indicates that interferon alpha (IFN-α) therapy is an effective treatment
option for a subgroup of patients with chronic hepatitis B virus (HBV) infection. It has been …

Highlights•Maternal HBeAg impacts Kupffer cells of the offspring to promote HBV
persistence.•HBeAg interacts with regulatory T cells to suppress natural killer cell …

Objective. Chronic hepatitis B liver fibrosis is an important intermediate link in the
development of liver cirrhosis. A retrospective cohort study was conducted in Longhua …

Hepatitis B e antigen (HBeAg) is a widely used marker both for chronic hepatitis B (CHB)
clinical management and HBV-related basic research. However, due to its high amino acid …