[HTML][HTML] SARS-CoV-2 variant biology: immune escape, transmission and fitness
AM Carabelli, TP Peacock, LG Thorne… - Nature Reviews …, 2023 - nature.com
In late 2020, after circulating for almost a year in the human population, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …
SARS-CoV-2 biology and host interactions
S Steiner, A Kratzel, GT Barut, RM Lang… - Nature Reviews …, 2024 - nature.com
The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …
SARS-CoV-2 and innate immunity: the good, the bad, and the “goldilocks”
BL Sievers, MTK Cheng, K Csiba, B Meng… - Cellular & Molecular …, 2024 - nature.com
An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …
immunity. Knowledge about this interplay can not only help us identify biological …
Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses
X Ou, G Xu, P Li, Y Liu, F Zan, P Liu, J Hu, X Lu… - Cell discovery, 2023 - nature.com
The bat coronaviruses (CoV) BANAL-20-52 and BANAL-20-236 are two newly identified
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) closely related …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) closely related …
High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike
Designing prefusion-stabilized SARS-CoV-2 spike is critical for the effectiveness of COVID-
19 vaccines. All COVID-19 vaccines in the US encode spike with K986P/V987P mutations to …
19 vaccines. All COVID-19 vaccines in the US encode spike with K986P/V987P mutations to …
Evolutionary remodelling of N‐terminal domain loops fine‐tunes SARS‐CoV‐2 spike
The emergence of SARS‐CoV‐2 variants has exacerbated the COVID‐19 global health
crisis. Thus far, all variants carry mutations in the spike glycoprotein, which is a critical …
crisis. Thus far, all variants carry mutations in the spike glycoprotein, which is a critical …
Receptor-binding domain (RBD) antibodies contribute more to SARS-CoV-2 neutralization when target cells express high levels of ACE2
Neutralization assays are experimental surrogates for the effectiveness of infection-or
vaccine-elicited polyclonal antibodies and therapeutic monoclonal antibodies targeting …
vaccine-elicited polyclonal antibodies and therapeutic monoclonal antibodies targeting …
COVID-19 Biogenesis and Intracellular Transport
AA Mironov, MA Savin, GV Beznoussenko - International journal of …, 2023 - mdpi.com
SARS-CoV-2 is responsible for the COVID-19 pandemic. The structure of SARS-CoV-2 and
most of its proteins of have been deciphered. SARS-CoV-2 enters cells through the …
most of its proteins of have been deciphered. SARS-CoV-2 enters cells through the …
Therapeutic and vaccine-induced cross-reactive antibodies with effector function against emerging Omicron variants
Currently circulating SARS-CoV-2 variants acquired convergent mutations at receptor-
binding domain (RBD) hot spots. Their impact on viral infection, transmission, and efficacy of …
binding domain (RBD) hot spots. Their impact on viral infection, transmission, and efficacy of …
Deep mutagenesis scanning using whole trimeric SARS-CoV-2 spike highlights the importance of NTD-RBD interactions in determining spike phenotype
R Kugathasan, K Sukhova, M Moshe, P Kellam… - PLoS …, 2023 - journals.plos.org
New variants of SARS-CoV-2 are continually emerging with mutations in spike associated
with increased transmissibility and immune escape. Phenotypic maps can inform the …
with increased transmissibility and immune escape. Phenotypic maps can inform the …