Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …

The spatial separation of DNA replication and gene transcription in the nucleus and protein
translation in the cytoplasm is a uniform principle of eukaryotic cells. This …

Allosteric regulation of protein function is widespread in biology, but is challenging for de
novo protein design as it requires the explicit design of multiple states with comparable free …

HIV-1 infection requires nuclear entry of the viral genome. Previous evidence suggests that
this entry proceeds through nuclear pore complexes (NPCs), with the 120× 60 nm capsid …

Dysfunction of protein quality control contributes to the cellular pathology of polyglutamine
(polyQ) expansion diseases and other neurodegenerative disorders associated with …

The nuclear export protein XPO1 is overexpressed in cancer, leading to the cytoplasmic
mislocalization of multiple tumor suppressor proteins. Existing XPO1-targeting agents lack …

CRM1 is a highly conserved, RanGTPase-driven exportin that carries proteins and RNPs
from the nucleus to the cytoplasm. We now explored the cargo-spectrum of CRM1 in depth …

Central to eukaryotic cell function, transport into and out of the nucleus is largely mediated
by members of the Importin (IMP) superfamily of transporters of α-and β-types. The first …

Nuclear import receptors, also called importins, mediate nuclear import of proteins and
chaperone aggregation-prone cargoes (eg, neurodegeneration-linked RNA-binding …

Nuclear pore complexes (NPCs) maintain a permeability barrier between the nucleus and
the cytoplasm through FG-repeat-containing nucleoporins (Nups). We previously proposed …