IFNγ is a cytokine with important roles in tissue homeostasis, immune and inflammatory
responses and tumour immunosurveillance. Signalling by the IFNγ receptor activates the …

Chronic overnutrition and obesity induces low-grade inflammation throughout the body.
Termed “meta-inflammation,” this chronic state of inflammation is mediated by macrophages …

Differential gene expression gives rise to the many cell types of complex organisms.
Enhancers regulate transcription by binding transcription factors (TFs), which in turn recruit …

Cells engaging in inflammation undergo drastic changes of their transcriptomes. In order to
tailor these alterations in gene expression to the requirements of the inflammatory process …

Delayed wound healing remains a challenge, and macrophages play an important role in
the inflammatory process of wound healing. Morphological changes in macrophages can …

Viruses infect virtually all forms of cellular life, and fungi are no exception. Knowledge
regarding the diverse fungal viruses, or mycoviruses, including their genome structures, host …

Interferon regulatory factors (IRFs) are a family of homologous proteins that regulate the
transcription of interferons (IFNs) and IFN-induced gene expression. As such they are …

Activation of macrophage proinflammatory and antimicrobial phenotypes is regulated by IFN-
γ and LPS via synergistic induction of canonical, inflammatory NF-κB target genes. However …

Diffuse large B-cell lymphoma (DLBCL) exhibits significant genetic heterogeneity which
contributes to drug resistance, necessitating development of novel therapeutic approaches …

Acupuncture is used in the treatment of a variety of inflammatory conditions and diseases.
However, the mechanisms of its anti-inflammatory action are complex and have not been …