[HTML][HTML] Chromosome conformation capture and beyond: toward an integrative view of chromosome structure and function
Rapidly developing technologies have recently fueled an exciting era of discovery in the
field of chromosome structure and nuclear organization. In addition to chromosome …
field of chromosome structure and nuclear organization. In addition to chromosome …
DNA repair: the search for homology
JE Haber - Bioessays, 2018 - Wiley Online Library
The repair of chromosomal double‐strand breaks (DSBs) by homologous recombination is
essential to maintain genome integrity. The key step in DSB repair is the RecA/Rad51 …
essential to maintain genome integrity. The key step in DSB repair is the RecA/Rad51 …
Transcription-coupled changes in nuclear mobility of mammalian cis-regulatory elements
To achieve guide RNA (gRNA) multiplexing and an efficient delivery of tens of distinct
gRNAs into single cells, we developed a molecular assembly strategy termed chimeric array …
gRNAs into single cells, we developed a molecular assembly strategy termed chimeric array …
Anomalous diffusion, spatial coherence, and viscoelasticity from the energy landscape of human chromosomes
M Di Pierro, DA Potoyan… - Proceedings of the …, 2018 - National Acad Sciences
The nucleus of a eukaryotic cell is a nonequilibrium system where chromatin is subjected to
active processes that continuously rearrange it over the cell's life cycle. Tracking the motion …
active processes that continuously rearrange it over the cell's life cycle. Tracking the motion …
Rad54 drives ATP hydrolysis-dependent DNA sequence alignment during homologous recombination
Homologous recombination (HR) helps maintain genome integrity, and HR defects give rise
to disease, especially cancer. During HR, damaged DNA must be aligned with an …
to disease, especially cancer. During HR, damaged DNA must be aligned with an …
Chromosome dynamics near the sol-gel phase transition dictate the timing of remote genomic interactions
Diverse antibody repertoires are generated through remote genomic interactions involving
immunoglobulin variable (VH), diversity (DH) and joining (JH) gene segments. How such …
immunoglobulin variable (VH), diversity (DH) and joining (JH) gene segments. How such …
[HTML][HTML] The mechanobiology of nuclear phase separation
The cell nucleus can be thought of as a complex, dynamic, living material, which functions to
organize and protect the genome and coordinate gene expression. These functions are …
organize and protect the genome and coordinate gene expression. These functions are …
Effects of active fluctuations on energetics of a colloidal particle: Superdiffusion, dissipation and entropy production
S Chaki, R Chakrabarti - Physica A: Statistical Mechanics and its …, 2019 - Elsevier
We consider a colloidal particle immersed in an active bath and derive a Smoluchowski
equation that governs the dynamics of the colloidal particle. We address this as active …
equation that governs the dynamics of the colloidal particle. We address this as active …
Target search by an imported conjugative DNA element for a unique integration site along a bacterial chromosome during horizontal gene transfer
R Arbel-Goren, SA McKeithen-Mead… - Nucleic acids …, 2023 - academic.oup.com
Integrative and conjugative elements (ICEs) are mobile genetic elements that can transfer by
conjugation to recipient cells. Some ICEs integrate into a unique site in the genome of their …
conjugation to recipient cells. Some ICEs integrate into a unique site in the genome of their …
Diffusion of nanoparticles with activated hopping in crowded polymer solutions
A long-distance hop of diffusive nanoparticles (NPs) in crowded environments was
commonly considered unlikely, and its characteristics remain unclear. In this work, we …
commonly considered unlikely, and its characteristics remain unclear. In this work, we …