The lack of in vitro tissue and organ models capable of mimicking human physiology
severely hinders the development and clinical translation of therapies and drugs with higher …

Notch signalling is an evolutionarily highly conserved signalling mechanism governing
differentiation and regulating homeostasis in many tissues. In this review, we discuss recent …

The blood–brain barrier (BBB) regulates the delivery of oxygen and important nutrients to
the brain through active and passive transport and prevents neurotoxins from entering the …

Prevalence of dementia continues to increase because of the aging population and limited
treatment options. Cerebral small vessel disease and Alzheimer disease are the two most …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL), a hereditary cerebral small vessel disease caused by …

Notch3 is one of four mammalian Notch proteins, which act as signalling receptors to control
cell fate in many developmental and adult tissue contexts. Notch signalling continues to be …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is a monogenic disease caused by NOTCH3 mutations …

Central nervous system diseases involving the parenchymal microvessels are frequently
associated with a 'microvasculopathy', which includes different levels of neurovascular unit …

The vascular endothelium is present in all organs and blood vessels, facilitates the
exchange of nutrients and waste throughout different organ systems in the body, and sets …

Brain ischemia is a common acute injury resulting from impaired blood flow to the brain.
Translation of effective drug candidates from experimental models to patients has …