Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …

The discovery of leptin changed the view of adipose tissue from that of a passive vessel that
stores fat to that of a dynamic endocrine organ that actively regulates behaviour and …

The Ser and Thr kinase AKT, also known as protein kinase B (PKB), was discovered 25
years ago and has been the focus of tens of thousands of studies in diverse fields of biology …

The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular
metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and …

Cancer-associated cachexia is a multi-organ weight loss syndrome, especially with a
wasting disorder of adipose tissue and skeletal muscle. Small extracellular vesicles (sEVs) …

It is widely known that branched chain amino acids (BCAA) are not only elementary
components for building muscle tissue but also participate in increasing protein synthesis in …

Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …

Branched chain amino acids (BCAA: leucine, valine, isoleucine) have key physiological
roles in the regulation of protein synthesis, metabolism, food intake and aging. Many studies …