Abstract Background The Infectious Diseases Society of America is committed to providing
up-to-date guidance on the treatment of antimicrobial-resistant infections. This guidance …

Therapy of invasive infections due to multidrug-resistant Enterobacteriaceae (MDR-E) is
challenging, and some of the few active drugs are not available in many countries. For …

Abstract Background The Infectious Diseases Society of America (IDSA) is committed to
providing up-to-date guidance on the treatment of antimicrobial-resistant infections. The …

Antimicrobial resistance is considered a major public-health issue. Policies recommended
by the World Health Organization (WHO) include research on new antibiotics. No new class …

Cefiderocol is an injectable siderophore cephalosporin discovered and being developed by
Shionogi & Co., Ltd., Japan. As with other β-lactam antibiotics, the principal antibacterial …

The discovery of antibiotics has long been regarded as one of the most significant medical
achievements of the twentieth century. Antibiotics have saved millions of lives (1) and …

Antimicrobial resistance has become one of the greatest threats to public health, with rising
resistance to carbapenems being a particular concern due to the lack of effective and safe …

Carbapenem-resistant Acinetobacter baumannii (CRAB) is a perilous nosocomial pathogen
causing substantial morbidity and mortality. Current treatment options for CRAB are limited …

ABSTRACT Cefiderocol (CFDC; S-649266), a novel parenteral siderophore cephalosporin
conjugated with a catechol moiety, has a characteristic antibacterial spectrum with a potent …

Iron is an essential nutrient for bacterial growth, replication, and metabolism. Humans store
iron bound to various proteins such as hemoglobin, haptoglobin, transferrin, ferritin, and …