Rationale Major depressive disorder is one of the leading global causes of disability, for
which the classic serotonergic psychedelics have recently reemerged as a potential …

To date, pharmacological treatments for mood and anxiety disorders and for drug
dependence show limited efficacy, leaving a large number of patients suffering severe and …

BackgroundRecent open-label trials show that psychedelics, such as ayahuasca, hold
promise as fast-onset antidepressants in treatment-resistant depression. MethodsTo test the …

Objectives: Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants
and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being …

Ayahuasca is the Quechua name for a tea obtained from the vine Banisteriopsis caapi, and
used for ritual purposes by the indigenous populations of the Amazon. The use of a variation …

Hallucinogens fall into several different classes, as broadly defined by pharmacological
mechanism of action, and chemical structure. These include psychedelics, entactogens …

Objective: To conduct a systematic literature review of animal and human studies reporting
anxiolytic or antidepressive effects of ayahuasca or some of its isolated alkaloids …

The word “psychedelic”(psyche (ie, the mind or soul) and delos (ie, to show)) has Greek
origin and was first coined by psychiatrist Humphry Osmond in 1956, who had been …

Background Ayahuasca is a psychoactive Amazonian brew which has emerging data
indicating that it has antidepressant and anxiolytic properties. Methods This paper uses data …

The potent hallucinogen N, N-dimethyltryptamine (DMT) has garnered significant interest in
recent years due to its profound effects on consciousness and its therapeutic …