Epstein-Barr virus: Biology and clinical disease

B Damania, SC Kenney, N Raab-Traub - Cell, 2022 - cell.com
Epstein-Barr virus (EBV) is a ubiquitous, oncogenic virus that is associated with a number of
different human malignancies as well as autoimmune disorders. The expression of EBV viral …

Epstein–Barr virus: how its lytic phase contributes to oncogenesis

Q Rosemarie, B Sugden - Microorganisms, 2020 - mdpi.com
Epstein–Barr Virus (EBV) contributes to the development of lymphoid and epithelial
malignancies. While EBV's latent phase is more commonly associated with EBV-associated …

A new model of Epstein-Barr virus infection reveals an important role for early lytic viral protein expression in the development of lymphomas

SD Ma, S Hegde, KH Young, R Sullivan… - Journal of …, 2011 - Am Soc Microbiol
Epstein-Barr virus (EBV) infects cells in latent or lytic forms, but the role of lytic infection in
EBV-induced lymphomas is unclear. Here, we have used a new humanized mouse model …

Novel therapeutics for Epstein–Barr virus

G Andrei, E Trompet, R Snoeck - Molecules, 2019 - mdpi.com
Epstein–Barr virus (EBV) is a human γ-herpesvirus that infects up to 95% of the adult
population. Primary EBV infection usually occurs during childhood and is generally …

Differences in gastric carcinoma microenvironment stratify according to EBV infection intensity: implications for possible immune adjuvant therapy

MJ Strong, G Xu, J Coco, C Baribault, DS Vinay… - PLoS …, 2013 - journals.plos.org
Epstein-Barr virus (EBV) is associated with roughly 10% of gastric carcinomas worldwide
(EBVaGC). Although previous investigations provide a strong link between EBV and gastric …

AP-1 homolog BZLF1 of Epstein–Barr virus has two essential functions dependent on the epigenetic state of the viral genome

M Kalla, A Schmeinck, M Bergbauer… - Proceedings of the …, 2010 - National Acad Sciences
EBV, a member of the herpes virus family, is a paradigm for human tumor viruses and a
model of viral latency amenable for study in vitro. It induces resting human B lymphocytes to …

A cancer-associated Epstein-Barr virus BZLF1 promoter variant enhances lytic infection

JA Bristol, R Djavadian, ER Albright… - PLoS …, 2018 - journals.plos.org
Latent Epstein-Barr virus (EBV) infection contributes to both B-cell and epithelial-cell
malignancies. However, whether lytic EBV infection also contributes to tumors is unclear …

Oncogenic properties of the EBV ZEBRA protein

D Germini, FB Sall, A Shmakova, J Wiels… - Cancers, 2020 - mdpi.com
Epstein Barr Virus (EBV) is one of the most common human herpesviruses. After primary
infection, it can persist in the host throughout their lifetime in a latent form, from which it can …

Antiviral drugs for EBV

JS Pagano, CB Whitehurst, G Andrei - Cancers, 2018 - mdpi.com
Epstein–Barr virus (EBV) infects up to 95% of the adult human population, with primary
infection typically occurring during childhood and usually asymptomatic. However, EBV can …

An Epstein-Barr Virus (EBV) mutant with enhanced BZLF1 expression causes lymphomas with abortive lytic EBV infection in a humanized mouse model

SD Ma, X Yu, JE Mertz, JE Gumperz… - Journal of …, 2012 - Am Soc Microbiol
Immunosuppressed patients are at risk for developing Epstein-Barr Virus (EBV)-positive
lymphomas that express the major EBV oncoprotein, LMP1. Although increasing evidence …