As the major excitatory neurotransmitter in the mammalian central nervous system,
glutamate plays a key role in many central pathologies, including gliomas, psychiatric …

An organism's response to stress requires activation of multiple brain regions. This can have
long‐lasting effects on synaptic transmission and plasticity that likely provide adaptive …

Some studies have demonstrated that ascorbic acid, similarly to ketamine, exhibits
antidepressant-like effects mediated, at least in part, by modulation of the glutamatergic …

Accumulating evidences indicate that endogenous modulators of excitatory synapses in the
mammalian brain are potential targets for treating neuropsychiatric disorders. Indeed …

A growing body of evidence demonstrates that quinoline compounds have attracted much
attention in the field of drug development. Accordingly, 4-phenylselenyl-7-chloroquinoline (4 …

Schizophrenia (SCZ), a serious mental disorder, is one of the leading causes of disease
burden worldwide. Exosomes, as a natural nanocarrier, are able to cross the blood-brain …

Experimental evidence has demonstrated that glutamate is an essential factor for
neurogenesis, whereas another line of research postulates that excessive glutamatergic …

Several mechanisms are associated with brain dysfunction during sepsis; one of the most
important are activation of microglia and astrocytes. Activation of glial cells induces changes …

Calcium waves are generated from the astrocyte endoplasmatic reticulum, in response to
neuronal electrochemical stimulation. The waves feed back on neurons, modulating …

The search for neural correlates of human consciousness in past decades has been based
on different assumptions and methods. Some researchers assume that conscious functions …