The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity

Y Xiong, BB Mi, Z Lin, YQ Hu, L Yu, KK Zha… - Military Medical …, 2022 - Springer
Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting
a variety of cell types, whose activity and interplay must be precisely mediated for effective …

Metal–organic frameworks and their composites for chronic wound healing: from bench to bedside

Y Xiong, Q Feng, L Lu, X Qiu, S Knoedler… - Advanced …, 2024 - Wiley Online Library
Chronic wounds are characterized by delayed and dysregulated healing processes. As
such, they have emerged as an increasingly significant threat. The associated morbidity and …

A whole‐course‐repair system based on neurogenesis‐angiogenesis crosstalk and macrophage reprogramming promotes diabetic wound healing

Y Xiong, Z Lin, P Bu, T Yu, Y Endo, W Zhou… - Advanced …, 2023 - Wiley Online Library
Diabetic wound (DW) therapy is currently a big challenge in medicine and strategies to
enhance neurogenesis and angiogenesis have appeared to be a promising direction …

All‐in‐one: multifunctional hydrogel accelerates oxidative diabetic wound healing through timed‐release of exosome and fibroblast growth factor

Y Xiong, L Chen, P Liu, T Yu, C Lin, C Yan, Y Hu… - Small, 2022 - Wiley Online Library
The treatment of diabetic wounds remains a major challenge in clinical practice, with chronic
wounds characterized by multiple drug‐resistant bacterial infections, angiopathy, and …

Exosomes derived from pioglitazone-pretreated MSCs accelerate diabetic wound healing through enhancing angiogenesis

Y Hu, R Tao, L Chen, Y Xiong, H Xue, L Hu… - Journal of …, 2021 - Springer
Background Enhanced angiogenesis can promote diabetic wound healing. Mesenchymal
stem cells (MSCs)-derived exosomes, which are cell-free therapeutics, are promising …

Emerging roles of exosomal miRNAs in diabetes mellitus

X He, G Kuang, Y Wu, C Ou - Clinical and translational …, 2021 - Wiley Online Library
Exosomes are small extracellular vesicles 40–160 nm in diameter that are secreted by
almost all cell types. Exosomes can carry diverse cargo including RNA, DNA, lipids …

[HTML][HTML] Mechanism and application of exosomes in the wound healing process in diabetes mellitus

D Li, N Wu - Diabetes Research and Clinical Practice, 2022 - Elsevier
Poor wound healing can seriously affect the health of patients with diabetes and result in a
heavy medical burden. Recently, exosomes have been considered the key substances …

Exosomal ncRNAs: Novel therapeutic target and biomarker for diabetic complications

YX Xu, SD Pu, X Li, ZW Yu, YT Zhang, XW Tong… - Pharmacological …, 2022 - Elsevier
Exosomes are discoid vesicles with a diameter of 40–160 nm. They are mainly derived from
the multivesicular body formed by the invagination of lysosomal particles in the cell, which …

[HTML][HTML] Hypoxic ADSC-derived exosomes enhance wound healing in diabetic mice via delivery of circ-Snhg11 and induction of M2-like macrophage polarization

R Shi, Y Jin, S Zhao, H Yuan, J Shi, H Zhao - Biomedicine & …, 2022 - Elsevier
Diabetes mellitus is a major cause of blindness and chronic ulcers in the working age
population worldwide. Former research have found that differentially expressed circular …

[HTML][HTML] Cryogenic 3D printed hydrogel scaffolds loading exosomes accelerate diabetic wound healing

Y Hu, B Wu, Y Xiong, R Tao, AC Panayi, L Chen… - Chemical Engineering …, 2021 - Elsevier
Diabetic wounds represent a pressing concern affecting the health and quality of life of
patients. Despite the continuous improvement in therapeutic strategy, diabetic wounds …