Membrane protrusions at the leading edge of cells, known as lamellipodia, drive cell
migration in many normal and pathological situations. Lamellipodial protrusion is powered …

Whereas some rare lipids contribute to the identity of cell organelles, we focus on the
abundant lipids that form the matrix of organelle membranes. Observations using bioprobes …

Mutations in more than 450 different genes have been associated with intellectual disability
(ID) and related cognitive disorders (CDs), such as autism. It is to be expected that this …

Ubiquitin chains are formed as structurally distinct polymers via different linkages, and
several chain types including K33-linkage remain uncharacterized. Here, we describe a role …

Copy number variation (CNV) at the 15q11. 2 region has been identified as a significant risk
locus for neurological and neuropsychiatric conditions such as schizophrenia (SCZ) and …

Transport carriers regulate membrane flow between compartments of the secretory and
endocytic pathways in eukaryotic cells. Carrier biogenesis is assisted by microtubules, actin …

Clathrin is considered the prototype vesicle coat protein whose self-assembly mediates
sorting of membrane cargo and recruitment of lipid modifiers. Detailed knowledge of clathrin …

Social impairment is frequently associated with mitochondrial dysfunction and altered
neurotransmission. Although mitochondrial function is crucial for brain homeostasis, it …

Altered excitatory/inhibitory (E/I) balance is implicated in neuropsychiatric and
neurodevelopmental disorders, but the underlying genetic etiology remains poorly …

Abstract Proteins of the Wiskott-Aldrich syndrome protein (WASP) family play a central role
in regulating actin cytoskeletal dynamics in a wide range of cellular processes. Genetic …