The kinesin, dynein, and myosin superfamily molecular motors have fundamental roles in
neuronal function, plasticity, morphogenesis, and survival by transporting cargos such as …

Neuronal function depends on axonal transport by kinesin superfamily proteins (KIFs).
KIF1A is the molecular motor that transports synaptic vesicle precursors, synaptic vesicles …

Changes in neuronal activity create local and transient changes in energy demands at
synapses. Here we discover a metabolic compartment that forms in vivo near synapses to …

The active zone of a presynaptic nerve terminal defines sites for neurotransmitter release. Its
protein machinery may be organized through liquid–liquid phase separation, a mechanism …

KIF1A is a kinesin family motor involved in the axonal transport of synaptic vesicle
precursors (SVPs) along microtubules (MTs). In humans, more than 10 point mutations in …

Kinesin motor proteins transport intracellular cargoes throughout cells by hydrolyzing ATP
and moving along microtubule tracks. Intramolecular autoinhibitory interactions have been …

Active zones (AZs) are presynaptic membrane domains mediating synaptic vesicle fusion
opposite postsynaptic densities (PSDs). At the Drosophila neuromuscular junction, the ELKS …

In axons, proper localization of proteins, vesicles, organelles, and other cargoes is
accomplished by the highly regulated coordination of kinesins and dyneins, molecular …

The location, size, and number of synapses critically influence the specificity and strength of
neural connections. In axons, synaptic vesicle (SV) and active zone (AZ) proteins are …

KIF1A is a kinesin superfamily motor protein that transports synaptic vesicle precursors in
axons. Cargo binding stimulates the dimerization of KIF1A molecules to induce processive …