Transition metals have been recognized and studied primarily in the context of their
essential roles as structural and metabolic cofactors for biomolecules that compose living …

Metal elements represent some of the most fundamental chemical building blocks of life and
are required to sustain the growth, development, and sustenance of all living organisms and …

Oligodendrocyte loss in neurological disease leaves axons vulnerable to damage and
degeneration, and activity-dependent myelination may represent an endogenous …

Copper is critical for the Central Nervous System (CNS) development and function. In
particular, different studies have shown the effect of copper at brain synapses, where it …

In the past decade, evidence for numerous roles of copper (Cu) in mammalian physiology
has grown exponentially. The discoveries of Cu involvement in cell signaling, autophagy …

This review focuses on the current knowledge on the involvement of metal ions in signaling
processes within the cell, in both physiological and pathological conditions. The first section …

Copper is an essential trace metal that is required for several important biological
processes, however, an excess of copper can be toxic to cells. Therefore, systemic and …

The prototype disease of Cu toxicity in human is Wilson disease, and cognitive impairment is
the presenting symptom of it. There is no study correlating Cu-induced excitotoxicity …

The copper (Cu) transporters ATPase copper-transporting alpha (ATP7A) and ATPase
copper-transporting beta (ATP7B) are essential for the normal function of the mammalian …

Zinc and copper ions can modulate the activity of glutamate receptors. However, labile zinc
and copper ions likely represent only the tip of the iceberg and other neuronal functions are …