New research has shown that the development of osteoarthritis (OA) is regulated by different
mechanisms of cell death and types of cytokines. Therefore, elucidating the mechanism of …

Abstract Necrostatin-1 (Nec-1) is a RIP1-targeted inhibitor of necroptosis, a form of
programmed cell death discovered and investigated in recent years. There are already …

Atopic dermatitis (AD) is a chronic skin disease caused by skin immune dyshomeostasis and
accompanied by severe pruritus. Although oxidative stress and mechanical scratching can …

Temporomandibular joint (TMJ) osteoarthritis is a common chronic degenerative disease of
the TMJ. In order to explore its aetiology and pathological mechanism, many animal models …

The temporomandibular joint (TMJ) is a specialized synovial joint that is crucial for the
movement and function of the jaw. TMJ osteoarthritis (TMJ OA) is the result of disc …

Introduction Mechanical loading enhances the progression of osteoarthritis. However, its
molecular mechanisms have not been established. Objective The aim of this review was to …

In vivo articular cartilage degeneration is an essential hallmark of osteoarthritis (OA),
involving chondrocyte senescence, extracellular matrix degradation, chondrocyte death …

Joint injuries are highly associated with cell death and development of posttraumatic
osteoarthritis (PTOA). The present study focused on necroptosis as a possible modality of …

Traumatic injuries of the knee joint result in a wide variety of pathomechanisms, which
contribute to the development of so-called posttraumatic osteoarthritis (PTOA). These …

Osteoarthritis (OA) is an age-related disease characterized by cartilage degeneration.
TNFR1-associated death domain protein (TRADD) is a key upstream molecule of TNF-α …