Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease
The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …
The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease
Abstract The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …
Nutrient sensing of mTORC1 signaling in cancer and aging
The mechanistic target of rapamycin complex 1 (mTORC1) is indispensable for preserving
cellular and organismal homeostasis by balancing the anabolic and catabolic processes in …
cellular and organismal homeostasis by balancing the anabolic and catabolic processes in …
Increased translation driven by non-canonical EZH2 creates a synthetic vulnerability in enzalutamide-resistant prostate cancer
Overcoming resistance to therapy is a major challenge in castration-resistant prostate
cancer (CRPC). Lineage plasticity towards a neuroendocrine phenotype enables CRPC to …
cancer (CRPC). Lineage plasticity towards a neuroendocrine phenotype enables CRPC to …
GATOR2 rings GATOR1 to speak to mTORC1
U Sahu, I Ben-Sahra - Molecular cell, 2023 - cell.com
The mechanistic target of rapamycin complex 1 (mTORC1) senses cellular leucine levels
through the GATOR1/2-Rag axis. Jiang et al. show that the Ring domains of GATOR2 …
through the GATOR1/2-Rag axis. Jiang et al. show that the Ring domains of GATOR2 …
Post-translational regulation of the mTORC1 pathway: A switch that regulates metabolism-related gene expression
Y Wang, T Engel, X Teng - Biochimica et Biophysica Acta (BBA)-Gene …, 2024 - Elsevier
The mechanistic target of rapamycin complex 1 (mTORC1) is a kinase complex that plays a
crucial role in coordinating cell growth in response to various signals, including amino acids …
crucial role in coordinating cell growth in response to various signals, including amino acids …
Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation
ML Valenstein, PV Lalgudi, JF Kedir, KJ Condon… - Nature, 2025 - nature.com
Activation of the mechanistic target of rapamycin complex 1 (mTORC1) requires its nutrient-
dependent recruitment to the surface of the lysosome, a process that is controlled by several …
dependent recruitment to the surface of the lysosome, a process that is controlled by several …
[HTML][HTML] Unveiling GATOR2 Function: Novel Insights from Drosophila Research
The multiprotein Target of Rapamycin (TOR) Complex 1 (TORC1) is a serine/threonine
kinase that stimulates anabolic metabolism and suppresses catabolism. Deregulation of …
kinase that stimulates anabolic metabolism and suppresses catabolism. Deregulation of …
New insights into GATOR2-dependent interactions and its conformational changes in amino acid sensing
C Yang, X Sun, G Wu - Bioscience Reports, 2024 - portlandpress.com
Eukaryotic cells coordinate growth under different environmental conditions via mechanistic
target of rapamycin complex 1 (mTORC1). In the amino-acid-sensing signalling pathway, the …
target of rapamycin complex 1 (mTORC1). In the amino-acid-sensing signalling pathway, the …
Reply to: Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation
J Chen, Y Ou, Y Liu - Nature, 2025 - nature.com
Activation of the mechanistic target of rapamycin complex 1 (mTORC1) requires its nutrient-
dependent recruitment to the surface of the lysosome, a process that is controlled by several …
dependent recruitment to the surface of the lysosome, a process that is controlled by several …