Stress induced by the accumulation of unfolded proteins in the endoplasmic reticulum (ER)
is a feature of specialized secretory cells and is also observed in many diseases, including …

Execution of fundamental cellular functions demands regulated protein folding homeostasis.
Endoplasmic reticulum (ER) is an active organelle existing to implement this function by …

A central function of the endoplasmic reticulum (ER) is to coordinate protein biosynthetic and
secretory activities in the cell. Alterations in ER homeostasis cause accumulation of …

Paneth cells are highly specialized epithelial cells of the small intestine, where they
coordinate many physiological functions. First identified more than a century ago on the …

Inflammatory bowel disease (IBD) represents a heterogeneous group of gastrointestinal
disorders, where commensal gut flora provokes an either (a) insufficient or (b) uncontrolled …

In rheumatoid arthritis (RA), macrophage is one of the major sources of inflammatory
mediators. Macrophages produce inflammatory cytokines through toll‐like receptor (TLR) …

Objective Although genome wide association studies have partly uncovered the genetic
basis of Crohn's disease (CD), it remains a challenge to link genetic polymorphisms to …

Several pathological processes, such as sepsis and inflammatory bowel disease (IBD), are
associated with impairment of intestinal epithelial barrier. Here, we investigated the role of …

The endoplasmic reticulum (ER)-induced unfolded protein response (ERUPR) is an
adaptive mechanism that is activated upon accumulation of misfolded proteins in the ER and …

The Unfolded Protein Response of the endoplasmic reticulum (UPRER) controls
proteostasis by adjusting the protein folding capacity of the ER to environmental and cell …