[HTML][HTML] Immunoregulatory and anti-inflammatory properties of Crocus sativus (Saffron) and its main active constituents: A review

M Zeinali, MR Zirak, SA Rezaee, G Karimi… - Iranian Journal of …, 2019 - ncbi.nlm.nih.gov
The medicinal uses of saffron, the dried stigmas of Crocus sativus L., have very long history
in food coloring agent, and flavoring agent as well as traditional medicine for the treatment of …

[HTML][HTML] Saffron; An updated review on biological properties with special focus on cardiovascular effects

S Ghaffari, N Roshanravan - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Objective Saffron as a natural product has long been used to impede and treat different
disorders including cardiovascular disease (CVDs). Stigma is the most principal part of …

Crocetin and crocin from saffron in cancer chemotherapy and chemoprevention

A Colapietro, A Mancini… - Anti-Cancer Agents …, 2019 - ingentaconnect.com
Introduction: Cancer is a disorder which has a powerful impact on the quality life and life
expectancy despite the increase in drugs and treatments available for cancer patients …

c-Kit modifies the inflammatory status of smooth muscle cells

L Song, L Martinez, ZM Zigmond, DR Hernandez… - PeerJ, 2017 - peerj.com
Background c-Kit is a receptor tyrosine kinase present in multiple cell types, including
vascular smooth muscle cells (SMC). However, little is known about how c-Kit influences …

Effects of crocin and saffron aqueous extract on gene expression of SIRT1, AMPK, LOX1, NF‐κB, and MCP‐1 in patients with coronary artery disease: A …

N Abedimanesh, B Motlagh… - Phytotherapy …, 2020 - Wiley Online Library
This trial evaluated the potential impacts of saffron aqueous extract (SAE) and its main
carotenoid on some of the atherosclerosis‐related gene expression and serum levels of …

Effects of saffron supplementation on glycemia and inflammation in patients with type 2 diabetes mellitus: A randomized double-blind, placebo-controlled clinical trial …

M Mobasseri, A Ostadrahimi, A Tajaddini… - Diabetes & Metabolic …, 2020 - Elsevier
Background New evidence indicates that overproduction of pro-inflammatory cytokines is
responsible for the development of diabetes difficulties. Some herbals such as saffron, may …

A review of how the saffron (Crocus sativus) petal and its main constituents interact with the Nrf2 and NF-κB signaling pathways

M Ghasemzadeh Rahbardar… - … Archives of Pharmacology, 2023 - Springer
The primary by-product of saffron (Crocus sativus) processing is saffron petals, which are
produced in large quantities but are discarded. The saffron petals contain a variety of …

A self-driven bioinspired nanovehicle by leukocyte membrane-hitchhiking for early detection and treatment of atherosclerosis

G Wu, W Wei, J Zhang, W Nie, L Yuan, Y Huang, L Zuo… - Biomaterials, 2020 - Elsevier
Atherosclerosis, as a silent killer, remains one of the most common causes of human
morbidity and mortality worldwide due to the lack of efficient strategy for early detection and …

A comprehensive review on biological activities and toxicology of crocetin

M Hashemi, H Hosseinzadeh - Food and Chemical Toxicology, 2019 - Elsevier
Natural products with high pharmacological potential and low toxicity have been considered
as the novel therapeutic agents. Crocetin is an active constituent of saffron (Crocus sativus …

The effects of saffron (Crocus sativus L.) in conjunction with concurrent training on body composition, glycaemic status, and inflammatory markers in obese men with …

B Hooshmand Moghadam… - British Journal of …, 2022 - Wiley Online Library
Aims Chronic inflammation is one of the major challenges in the management of obesity and
type 2 diabetes mellitus (T2DM). Our primary aim was to assess the anti‐inflammatory …