B-cell lymphoma is a group of hematological malignancies with high clinical and biological
heterogeneity. The pathogenesis of B-cell lymphoma involves a complex interaction …

Abstract Interleukin-1 receptor-associated kinases (IRAK1, IRAK2, IRAK3 [IRAK-M], and
IRAK4) are serine-threonine kinases involved in toll-like receptor and interleukin-1 signaling …

Macrophages are immune cells that originate from embryogenesis or from the differentiation
of monocytes. They can adopt numerous phenotypes depending on their origin, tissue …

To identify new therapeutic targets in acute myeloid leukemia (AML), we performed small-
molecule and small-interfering RNA (siRNA) screens of primary AML patient samples. In …

A large amount of circumstantial evidence has accumulated suggesting that Toll-like
receptor (TLR) signals are involved in driving chronic lymphocytic leukemia (CLL) cell …

Simple Summary Tumor-associated macrophages (TAM) represent a leading component of
the tumor microenvironment in hematologic malignancies. TAM could display antitumor …

Microenvironment contributes to follicular lymphoma (FL) pathogenesis and impacts survival
with macrophages playing a controversial role. In the present study, using FL primary …

Pacritinib, potent inhibitor of Janus kinase 2 (JAK2), JAK2V617F, and fms-like receptor
tyrosine kinase 3, is in Phase III development in myelofibrosis. Among type 1 inhibitors …

Translating the genetic and epigenetic heterogeneity underlying human cancers into
therapeutic strategies is an ongoing challenge. Large-scale sequencing efforts have …

Tumour microenvironment (TME) is a key determinant of tumour growth and metastasis.
TME could be very different for each type and location of tumour and TME may change …