Psychosis is a common and distressing symptom in people with Alzheimer disease, and few
safe and effective treatments are available. However, new approaches to symptom …

Microglia are specialized dynamic immune cells in the central nervous system (CNS) that
plays a crucial role in brain homeostasis and in disease states. Persistent …

Brain region-specific degeneration and somatic expansions of the mutant Huntingtin (mHTT)
CAG tract are key features of Huntington's disease (HD). However, the relationships among …

Objective To assess the prevalence, timing, and functional impact of psychiatric, cognitive,
and motor abnormalities in Huntington disease (HD) gene carriers, we analyzed …

Abstract Huntington's disease (HD)(OMIM 143100) is caused by an expanded CAG repeat
tract in the HTT gene. The inherited CAG length is known to expand further in somatic and …

Huntington's disease (HD) is a rare, inherited disorder with a broad spectrum of
manifestations that vary with disease severity and progression. Although genetic testing can …

Brain-derived neurotrophic factor (BDNF) is a major neurotrophin whose loss or interruption
is well established to have numerous intersections with the pathogenesis of progressive …

Background The relationship between neuropsychiatric symptoms (NPS) and other clinical
dimensions in Huntington's disease (HD) is controversial. This longitudinal study analyzed …

Background Somatic mutations arising from the brain have recently emerged as significant
contributors to neurodevelopmental disorders, including childhood intractable epilepsy and …

Huntington's disease (HD) is an autosomal-dominant progressive neurodegenerative
disease that manifests with a triad of symptoms including motor dysfunctions, cognitive …