Chronic pruritus is a complex multifactorial symptom associated with many different
diseases that represents a diagnostic and therapeutic challenge for physicians. In order to …

Background The patient burden and quality of life (QOL) impact of atopic dermatitis (AD) in
the United States population is not well established. Objective To elucidate the patient …

Psoriasis is not optimally controlled in spite of newly developed treatments, possibly due to
the difficulty of objectively quantifying the disease's severity, considering the limitations of …

Aims: To determine the minimal clinically important difference (MCID) of the Dermatology
Life Quality Index (DLQI) and its responsiveness to change in inflammatory skin diseases …

Background The relationship between atopic dermatitis (AD), anxiety and depression in the
US adult population is not well established. Objectives To determine the relationship of AD …

Background Atopic dermatitis (AD) is associated with skin pain. However, little is known
about the prevalence and associations of pain in AD. Objective To characterize the …

510 S. Ständer et al. the study design of randomized controlled trials (RCT). The aim of
including PRO is to demonstrate a clinical treatment benefit of the new substance from the …

Background The substance P/neurokinin 1 receptor pathway is critical in chronic pruritus;
anecdotal evidence suggests that antagonism of this pathway can reduce chronic itch …

Psoriasis encompasses a group of related immune‐mediated inflammatory skin diseases
that affect up to 3% of the population. These diseases are heritable and over 40 genetic …

Composite measures that combine different types of indicators are widely used in medical
research; to evaluate health systems, as outcomes in clinical trials and patient-reported …