Calcium ions are ubiquitous intracellular messengers. An increase in the cytosolic Ca2+
concentration activates many proteins, including calmodulin and the Ca2+/calmodulin …

Ca2+, as a second messenger in cells, enables organisms to adapt to different
environmental stresses by rapidly sensing and responding to external stimuli. In recent …

Calcineurin is a highly conserved Ca2+/calmodulin-dependent serine/threonine-specific
protein phosphatase that orchestrates cellular Ca2+ signaling responses. In Cryptococcus …

Calcineurin governs stress survival, sexual differentiation, and virulence of the human fungal
pathogen Cryptococcus neoformans. Calcineurin is activated by increased Ca2+ levels …

Cryptococcus neoformans and Cryptococcus gattii species complexes are the etiologic
agents of cryptococcosis. We have deciphered the roles of three ABC transporters, Afr1 …

Ca 2+/calcineurin signaling pathway is crucial in regulating growth, stress response and
pathogenicity of phytopathogenic fungi. However, there is little information about the …

Sensing, responding, and adapting to the surrounding environment are crucial for all living
organisms to survive, proliferate, and differentiate in their biological niches. This ability is …

The calcineurin-CRZ1 signaling pathway is conserved from yeasts to humans, and is
involved in survival, tolerance to biotic and abiotic stress conditions, virulence, and drug …

Cryptococcus neoformans is a ubiquitous, opportunistic fungal pathogen that kills almost
200,000 people worldwide each year. It is acquired when mammalian hosts inhale the …

Cryptococcus neoformans is an encapsulated yeast-like fungus capable of causing life
threatening meningoencephalitis in patients with impaired immunity. This microbe primarily …