There is an urgent need for antiviral agents that treat severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection. We screened a library of 1900 clinically safe drugs …

Lymphocytic choriomeningitis virus (LCMV) is a common infection of rodents first identified
over eighty years ago in St. Louis, MO, USA It is best known for its application in …

The Bunyavirales order accommodates related viruses (bunyaviruses) with segmented,
linear, single-stranded, negative-or ambi-sense RNA genomes. Their glycoproteins form …

Tissue-resident memory T cells (TRM) persist at sites of prior infection and have been shown
to enhance pathogen clearance by recruiting circulating immune cells and providing …

Chronic infections induce T cells showing impaired cytokine secretion and up-regulated
expression of inhibitory receptors such as PD-1. What determines the acquisition of this …

Arenaviruses such as Lassa virus (LASV) can cause severe hemorrhagic fever in humans.
As a major impediment to vaccine development, delayed and weak neutralizing antibody …

In chronic inflammatory diseases of the central nervous system (CNS), immune cells
persisting behind the blood-brain barrier are supposed to promulgate local tissue …

We have documented that the nucleoprotein (NP) of the prototypic arenavirus lymphocytic
choriomeningitis virus is an antagonist of the type I interferon response. In this study we …

Background The use of antimicrobials in layer poultry production for improved production,
growth promotion, prophylaxis and treatment purposes has contributed to the development …

Reverse genetics systems have been established for all major groups of plant DNA and
positive-strand RNA viruses, and our understanding of their infection cycles and …