Lysosomes are catabolic organelles that contribute to the degradation of intracellular
constituents through autophagy and of extracellular components through endocytosis …

Abstract Drug-induced calculi represent 1–2% of all renal calculi. The drugs reported to
produce calculi may be divided into two groups. The first one includes poorly soluble drugs …

At least 10% of adults and nearly all children who receive renal-replacement therapy have
an inherited kidney disease. These patients rarely die when their disease progresses and …

Luminal acidification is of pivotal importance for the physiology of the secretory and
endocytic pathways and its diverse trafficking events. Acidification by the proton-pumping V …

The endolysosomal system sustains the reabsorptive activity of specialized epithelial cells.
Lysosomal storage diseases such as nephropathic cystinosis cause a major dysfunction of …

Genetically modified mice have been studied for more than fifteen years as models of cystic
fibrosis (CF). The large amount of experimental data generated illuminates the complex …

Cystic fibrosis is the most common life-threatening recessively inherited disease in
Caucasians. Due to early provision of care in specialized reference centers and more …

Background Cystic fibrosis (CF, mucoviscidosis) is caused by mutations in the gene
encoding CF transmembrane conductance regulator (CFTR), which is a chloride and …

Abstract Cadmium (Cd 2+) is a nonessential divalent metal ion that causes toxicity in
multiple organs in humans. In order for toxicity to occur Cd 2+ must first enter cells by …

Current understanding of fibrosis remains incomplete despite the increasing burden of
related diseases. Preclinical models are used to dissect the pathogenesis and dynamics of …