Mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator
undermine many host defense systems by inhibiting the function of airway-surface liquid …

TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

Our understanding of the multiorgan pathology of cystic fibrosis (CF) has improved
impressively during the last decades, but we still lack a full comprehension of the disease …

Genetically modified mice have been studied for more than fifteen years as models of cystic
fibrosis (CF). The large amount of experimental data generated illuminates the complex …

For almost two decades, it has been postulated that calcium-activated Cl–channels (CaCCs)
play a role in airway epithelial Cl–secretion, but until recently, the molecular identity of the …

Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the gene
encoding the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel …

Cystic fibrosis is the most common life-threatening recessively inherited disease in
Caucasians. Due to early provision of care in specialized reference centers and more …

Rationale: Although airway abnormalities are common in patients with cystic fibrosis (CF), it
is unknown whether they are all secondary to postnatal infection and inflammation, which …

This review briefly describes the most common chronic inflammatory diseases in childhood,
such as cystic fibrosis (CF), inflammatory bowel diseases (IBDs), juvenile idiopathic arthritis …

One of the key features associated with the substantial increase in life expectancy for
individuals with CF is an elevated predisposition to cancer, firmly established by recent …