Mitochondrial metabolism: a predictive biomarker of radiotherapy efficacy and toxicity
F Taghizadeh-Hesary, M Houshyari… - Journal of Cancer …, 2023 - Springer
Introduction Radiotherapy is a mainstay of cancer treatment. Clinical studies revealed a
heterogenous response to radiotherapy, from a complete response to even disease …
heterogenous response to radiotherapy, from a complete response to even disease …
Estrogen receptor blockade and radiation therapy cooperate to enhance the response of immunologically cold ER+ breast cancer to immunotherapy
KA O'Leary, AM Bates, WJ Jin, BM Burkel… - Breast Cancer …, 2023 - Springer
Background Most patients with estrogen receptor positive (ER+) breast cancer do not
respond to immune checkpoint inhibition (ICI); the tumor microenvironment (TME) of these …
respond to immune checkpoint inhibition (ICI); the tumor microenvironment (TME) of these …
[HTML][HTML] A review of therapeutic agents for breast cancer with potentially radiosensitizing properties
Z Zhang, D Lim, Z Feng - Radiation Medicine and Protection, 2024 - Elsevier
Breast cancer is the most frequently diagnosed malignant tumor in women worldwide and
the leading cause of cancer death. Radiotherapy for breast cancer is readily accepted and …
the leading cause of cancer death. Radiotherapy for breast cancer is readily accepted and …
StackER: a novel SMILES-based stacked approach for the accelerated and efficient discovery of ERα and ERβ antagonists
The role of estrogen receptors (ERs) in breast cancer is of great importance in both clinical
practice and scientific exploration. However, around 15–30% of those affected do not see …
practice and scientific exploration. However, around 15–30% of those affected do not see …
Molecular subtypes of breast cancer predicting clinical benefits of radiotherapy after breast-conserving surgery: a propensity-score-matched cohort study
SK Hung, HJ Yang, MS Lee, DW Liu, LC Chen… - Breast Cancer …, 2023 - Springer
Background Based on the molecular expression of cancer cells, molecular subtypes of
breast cancer have been applied to classify patients for predicting clinical outcomes and …
breast cancer have been applied to classify patients for predicting clinical outcomes and …
Androgen and oestrogen receptor co-expression determines the efficacy of hormone receptor-mediated radiosensitisation in breast cancer
AR Michmerhuizen, LM Lerner, C Ward… - British Journal of …, 2022 - nature.com
Purpose Radiation therapy (RT) and hormone receptor (HR) inhibition are used for the
treatment of HR-positive breast cancers; however, little is known about the interaction of the …
treatment of HR-positive breast cancers; however, little is known about the interaction of the …
Breast cancer cells are sensitized by piperine to radiotherapy through estrogen receptor-α mediated modulation of a key NHEJ repair protein-DNA-PK
K Shaheer, BRS Prabhu, HS Ali, D Lakshmanan-M - Phytomedicine, 2024 - Elsevier
Background Non-homologous end joining, an important DNA-double-stranded break repair
pathway, plays a prominent role in conferring resistance to radiotherapeutic agents …
pathway, plays a prominent role in conferring resistance to radiotherapeutic agents …