The role of O-glycosylation in human disease
O-glycosylation is a highly frequent post-translation modification of proteins, with important
functional implications in both physiological and disease contexts. The biosynthesis of O …
functional implications in both physiological and disease contexts. The biosynthesis of O …
Demystifying the O-GlcNAc code: a systems view
Post-translational modification with O-linked β-N-acetylglucosamine (O-GlcNAc), a process
referred to as O-GlcNAcylation, occurs on a vast variety of proteins. Mounting evidence in …
referred to as O-GlcNAcylation, occurs on a vast variety of proteins. Mounting evidence in …
Molecular recognition of GalNAc in mucin-type O-glycosylation
I Sanz-Martinez, S Pereira, P Merino… - Accounts of Chemical …, 2023 - ACS Publications
Conspectus N-Acetylgalactosamine (GalNAc)-type O-glycosylation is an essential
posttranslational modification (PTM) that plays fundamental roles in biology. Malfunction of …
posttranslational modification (PTM) that plays fundamental roles in biology. Malfunction of …
O-glycosylation and its role in therapeutic proteins
N Thompson, W Wakarchuk - Bioscience Reports, 2022 - portlandpress.com
Protein glycosylation is ubiquitous throughout biology. From bacteria to humans, this post
translational modification with sophisticated carbohydrate structures plays a profound role in …
translational modification with sophisticated carbohydrate structures plays a profound role in …
Exploring the glycosylation of mucins by use of O-glycodomain reporters recombinantly expressed in glycoengineered HEK293 cells
A Konstantinidi, R Nason, T Čaval, L Sun… - Journal of Biological …, 2022 - ASBMB
Mucins and glycoproteins with mucin-like regions contain densely O-glycosylated domains
often found in tandem repeat (TR) sequences. These O-glycodomains have traditionally …
often found in tandem repeat (TR) sequences. These O-glycodomains have traditionally …
The effects of diet and gut microbiota on the regulation of intestinal mucin glycosylation
Intestinal mucins glycosylation is regulated by host cues and environmental signals from the
microbiome and diets. However, the mechanisms responsible for the dialogue between …
microbiome and diets. However, the mechanisms responsible for the dialogue between …
The effect of a methyl group on structure and function: Serine vs. threonine glycosylation and phosphorylation
JJ Barchi Jr, CN Strain - Frontiers in Molecular Biosciences, 2023 - frontiersin.org
A variety of glycan structures cover the surface of all cells and are involved in myriad
biological processes, including but not limited to, cell adhesion and communication, protein …
biological processes, including but not limited to, cell adhesion and communication, protein …
HOTGpred: Enhancing human O-linked threonine glycosylation prediction using integrated pretrained protein language model-based features and multi-stage feature …
NT Pham, Y Zhang, R Rakkiyappan… - Computers in Biology and …, 2024 - Elsevier
O-linked glycosylation is a complex post-translational modification (PTM) in human proteins
that plays a critical role in regulating various cellular metabolic and signaling pathways. In …
that plays a critical role in regulating various cellular metabolic and signaling pathways. In …
Atomic and Specificity Details of Mucin 1 O-Glycosylation Process by Multiple Polypeptide GalNAc-Transferase Isoforms Unveiled by NMR and Molecular Modeling
The large family of polypeptide GalNAc-transferases (GalNAc-Ts) controls with precision
how GalNAc O-glycans are added in the tandem repeat regions of mucins (eg, MUC1) …
how GalNAc O-glycans are added in the tandem repeat regions of mucins (eg, MUC1) …
ISOGlyP: de novo prediction of isoform-specific mucin-type O-glycosylation
Mucin-type O-glycosylation is one of the most common posttranslational modifications of
proteins. The abnormal expression of various polypeptide GalNAc-transferases (GalNAc-Ts) …
proteins. The abnormal expression of various polypeptide GalNAc-transferases (GalNAc-Ts) …