Most cancer-related deaths are a result of metastasis, and thus the importance of this
process as a target of therapy cannot be understated. By asking 'how can we effectively treat …

Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

Metastatic castration-resistant prostate cancer (PC) is the final stage of PC that acquires
resistance to androgen deprivation therapies (ADT). Despite progresses in understanding of …

Athymic nude mice, a murine strain bearing spontaneous deletion in the Foxn1 gene that
causes deteriorated or absent thymus (which results in inhibited immune system with …

Metastatic disease is the principal cause of prostate-cancer-related mortality. Our ability to
accurately recapitulate the spread of prostate cancer to bone—the most common site of …

Although the current murine model of bone metastasis using intracardiac (IC) injection
successfully recapitulates the process of bone metastasis, further progress in the study of …

Breast cancer is the most commonly diagnosed cancer in the USA. Although advances in
treatment over the past several decades have significantly improved the outlook for this …

In the biomedical and pharmaceutical fields, cyclodextrin (CD) is undoubtedly one of the
most frequently used macrocyclic compounds as the host molecule because it has good …

Background and Aims Bone is the second most frequent site of metastasis for HCC, which
leads to an extremely poor prognosis. HCC bone metastasis is typically osteolytic, involving …

Primary renal neoplasms are uncommon in domestic animals; they are usually malignant in
dogs, cats, and horses and benign in cattle. Nephroblastoma also has a unique origin in the …