Abstract P-glycoprotein (P-gp) is an ATP-dependent efflux pump encoded by the MDR1
gene in humans, known to mediate multidrug resistance of neoplastic cells to cancer …

Background There is an expanding field of research investigating the benefits of medicines
with multiple mechanisms of action across neurological disorders. N‐acetylcysteine (NAC) …

Reactive oxygen species (ROS) are constantly generated and eliminated in the biological
system, and play important roles in a variety of normal biochemical functions and abnormal …

Oxidative stress generated by an imbalance between reactive oxygen species (ROS) and
antioxidants contributes to the pathogenesis of arthritis, cancer, cardiovascular, liver and …

BACKGROUND: The cytosolic glutathione transferases (GSTs) comprise a super family of
proteins that can be categorized into multiple classes with a mixture of highly specific and …

Over the last decade fundamentally new features have been revealed for the participation of
glutathione and glutathione-dependent enzymes (glutathione transferase and glutaredoxin) …

Plants of the genus Terminalia are amongst the most widely used plants for traditional
medicinal purposes worldwide. Many species are used for their antibacterial, antifungal …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Parthenolide is one of the main components responsible for the anti-inflammatory property
of Feverfew. Recently, parthenolide has shown to induce apoptosis in cancer cells. Here we …

Anticancer therapy is frequently efficient in early stages of the disease, whereas advanced
tumors are usually resistant to the same treatments. The molecular basis for this change is …