Mechanisms of spermidine-induced autophagy and geroprotection
Aging involves the systemic deterioration of all known cell types in most eukaryotes. Several
recently discovered compounds that extend the healthspan and lifespan of model organisms …
recently discovered compounds that extend the healthspan and lifespan of model organisms …
Polyamines in Parkinson's disease: balancing between neurotoxicity and neuroprotection
S Vrijsen, M Houdou, A Cascalho… - Annual Review of …, 2023 - annualreviews.org
The polyamines putrescine, spermidine, and spermine are abundant polycations of vital
importance in mammalian cells. Their cellular levels are tightly regulated by degradation …
importance in mammalian cells. Their cellular levels are tightly regulated by degradation …
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Viruses manipulate cellular metabolism and macromolecule recycling processes like
autophagy. Dysregulated metabolism might lead to excessive inflammatory and …
autophagy. Dysregulated metabolism might lead to excessive inflammatory and …
Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression
Spermidine is a natural polyamine that has health benefits and extends life span in several
species. Deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH) are key …
species. Deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH) are key …
Warmth prevents bone loss through the gut microbiota
C Chevalier, S Kieser, M Çolakoğlu, N Hadadi, J Brun… - Cell metabolism, 2020 - cell.com
Osteoporosis is the most prevalent metabolic bone disease, characterized by low bone
mass and microarchitectural deterioration. Here, we show that warmth exposure (34° C) …
mass and microarchitectural deterioration. Here, we show that warmth exposure (34° C) …
[HTML][HTML] Polyamine catabolism and oxidative damage
TM Stewart, TT Dunston, PM Woster… - Journal of Biological …, 2018 - Elsevier
Polyamines (PAs) are indispensable polycations ubiquitous to all living cells. Among their
many critical functions, PAs contribute to the oxidative balance of the cell. Beginning with …
many critical functions, PAs contribute to the oxidative balance of the cell. Beginning with …
Dietary and gut microbiota polyamines in obesity-and age-related diseases
B Ramos-Molina, MI Queipo-Ortuño… - Frontiers in …, 2019 - frontiersin.org
The polyamines putrescine, spermidine, and spermine are widely distributed polycationic
compounds essential for cellular functions. Intracellular polyamine pools are tightly …
compounds essential for cellular functions. Intracellular polyamine pools are tightly …
[HTML][HTML] Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models
Nominal effect concentrations from in vitro toxicity assays may lead to inaccurate estimations
of in vivo toxic doses because the nominal concentration poorly reflects the concentration at …
of in vivo toxic doses because the nominal concentration poorly reflects the concentration at …
Spermidine–an old molecule with a new age-defying immune function
K Chamoto, B Zhang, M Tajima, T Honjo… - Trends in cell …, 2024 - cell.com
Polyamines–putrescine, spermidine, and spermine–are widely distributed aliphatic
compounds known to regulate important biological processes in prokaryotic and eukaryotic …
compounds known to regulate important biological processes in prokaryotic and eukaryotic …
Polyamine immunometabolism: central regulators of inflammation, cancer and autoimmunity
Polyamines are ubiquitous, amine-rich molecules with diverse processes in biology. Recent
work has highlighted that polyamines exert profound roles on the mammalian immune …
work has highlighted that polyamines exert profound roles on the mammalian immune …