Combination cancer immunotherapies: Emerging treatment strategies adapted to the tumor microenvironment
N Kirchhammer, MP Trefny, P Auf der Maur… - Science translational …, 2022 - science.org
Immune checkpoint blockade (ICB) has revolutionized cancer treatment. However,
resistance to ICB occurs frequently due to tumor-intrinsic alterations or extrinsic factors in the …
resistance to ICB occurs frequently due to tumor-intrinsic alterations or extrinsic factors in the …
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity
PDA Vignali, K DePeaux, MLJ Watson, C Ye… - Nature …, 2023 - nature.com
CD8+ T cells are critical for elimination of cancer cells. Factors within the tumor
microenvironment (TME) can drive these cells to a hypofunctional state known as …
microenvironment (TME) can drive these cells to a hypofunctional state known as …
Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity
B Prinzing, CC Zebley, CT Petersen, Y Fan… - Science translational …, 2021 - science.org
Chimeric antigen receptor (CAR) T cell therapy is revolutionizing cancer immunotherapy for
patients with B cell malignancies and is now being developed for solid tumors and chronic …
patients with B cell malignancies and is now being developed for solid tumors and chronic …
'Stem-like' precursors are the fount to sustain persistent CD8+ T cell responses
D Zehn, R Thimme, E Lugli, GP de Almeida… - Nature …, 2022 - nature.com
Virus-specific CD8+ T cells that differentiate in the context of resolved versus persisting
infections exhibit divergent phenotypic and functional characteristics, which suggests that …
infections exhibit divergent phenotypic and functional characteristics, which suggests that …
Metabolic adaptation of lymphocytes in immunity and disease
NM Chapman, H Chi - Immunity, 2022 - cell.com
Adaptive immune responses mediated by T cells and B cells are crucial for protective
immunity against pathogens and tumors. Differentiation and function of immune cells require …
immunity against pathogens and tumors. Differentiation and function of immune cells require …
Nanoparticle‐mediated radiotherapy remodels the tumor microenvironment to enhance antitumor efficacy
Radiotherapy (RT) uses ionizing radiation to eradicate localized tumors and, in rare cases,
control tumors outside of the irradiated fields via stimulating an antitumor immune response …
control tumors outside of the irradiated fields via stimulating an antitumor immune response …
IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases
The success of chimeric antigen receptor (CAR) T cell therapy in treating several
hematopoietic malignancies has been difficult to replicate in solid tumors, in part because of …
hematopoietic malignancies has been difficult to replicate in solid tumors, in part because of …
[HTML][HTML] The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function
M Wenes, A Jaccard, T Wyss, N Maldonado-Pérez… - Cell Metabolism, 2022 - cell.com
Glycolysis, including both lactate fermentation and pyruvate oxidation, orchestrates CD8+ T
cell differentiation. However, how mitochondrial pyruvate metabolism and uptake controlled …
cell differentiation. However, how mitochondrial pyruvate metabolism and uptake controlled …
Targeting the activity of T cells by membrane surface redox regulation for cancer theranostics
C Shi, Q Zhang, Y Yao, F Zeng, C Du, S Nijiati… - Nature …, 2023 - nature.com
T cells play a determining role in the immunomodulation and prognostic evaluation of
cancer treatments relying on immune activation. While specific biomarkers determine the …
cancer treatments relying on immune activation. While specific biomarkers determine the …