Arylamine N-acetyltransferase 2 has been related to drug side effects and cancer
susceptibility; its protein structure and acetylation capacity results from the polymorphism's …

In humans, there are two arylamine N-acetyltransferase genes that encode functional
enzymes (NAT1 and NAT2) as well as one pseudogene, all of which are located together on …

Unfavorable treatment outcomes for tuberculosis (TB) treatment might result from altered
plasma exposure to antitubercular drugs in TB patients. The present study investigated the …

Abstract The Sahel/Savannah belt harbors diverse populations with different demographic
histories and different subsistence patterns. However, populations from this large African …

Background Human population history in the Holocene was profoundly impacted by
changes in lifestyle following the invention and adoption of food-production practices. These …

Human leukocyte antigen (HLA) genes play a key role in the immune response to infectious
diseases, some of which are highly prevalent in specific environments, like malaria in sub …

Objectives Archeological evidence shows that first nomadic pastoralists came to the African
Sahel from northeastern Sahara, where milking is reported by~ 7.5 ka. A second wave of …

Background Pellagra is caused by niacin (vitamin B3) deficiency and patients with pellagra
present with a characteristic rash. Isoniazid disrupts intracellular niacin synthesis and might …

The genetic variation of our species reflects human demographic history and adaptation to
diverse local environments. Part of this genetic variation affects individual responses to …

Background and objectives N-acetyltransferase 2 (NAT2) metabolize several drugs
including isoniazid. We investigated the effect of genotype, geographical difference, and …