Ankylosing spondylitis (AS) is a chronic inflammatory disorder of unknown aetiology. Unlike
other systemic autoimmune diseases, in AS, the innate immune system has a dominant role …

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder that primarily
affects the joints. One hypothesis for the pathogenesis of RA is that disease begins at …

Spondyloarthritis (SpA) is characterized by the infiltration of innate and adaptive immune
cells into entheses and bone marrow. Molecular, cellular and imaging evidence …

IL-23 is considered a critical regulator of IL-17 in Th17 cells; however, its requirement for
inducing IL-17 production in other human immune subsets remains incompletely …

Rheumatoid arthritis (RA) is a chronic destructive autoimmune disease of the joints which
causes significant pain, functional disability, and mortality. Although aberrant immune cell …

Psoriatic arthritis (PsA) is a heterogeneous disease involving multiple potential tissue
domains. Most outcome measures used so far in randomized clinical trials do not sufficiently …

Aberrant activation and dysregulation of immune system is a common feature of many forms
of inflammatory arthritis. Since their identification as a distinctive population of leukocytes …

Spondyloarthritis (SpA) is a heterogeneous group of chronic inflammatory diseases of
unknown etiology. Over time, the plethora of cellular elements involved in its pathogenesis …

The breadth of bone lesion types seen in spondyloarthritis is unprecedented in medicine
and includes increased bone turnover, bone loss and fragility, osteitis, osteolysis and …

Abstract Interleukin (IL)‐23–independent IL‐17A production has been suggested to be
involved in persistent manifestations of psoriatic disease, including anti–IL‐12/23–refractory …