Improving lung health in low-income and middle-income countries: from challenges to solutions
Low-income and middle-income countries (LMICs) bear a disproportionately high burden of
the global morbidity and mortality caused by chronic respiratory diseases (CRDs), including …
the global morbidity and mortality caused by chronic respiratory diseases (CRDs), including …
Post-tuberculosis lung disease: clinical review of an under-recognised global challenge
An estimated 58 million people have survived tuberculosis since 2000, yet many of them will
suffer from post-tuberculosis lung disease (PTLD). PTLD results from a complex interplay …
suffer from post-tuberculosis lung disease (PTLD). PTLD results from a complex interplay …
Post-tuberculosis lung health: perspectives from the First International Symposium
BW Allwood, MM Van Der Zalm… - … of Tuberculosis and …, 2020 - ingentaconnect.com
ALTHOUGH CURABLE, TB frequently leaves the individual with chronic physical and
psycho-social impairment, but these consequences have been largely neglected. The 1st …
psycho-social impairment, but these consequences have been largely neglected. The 1st …
Patient outcomes associated with post-tuberculosis lung damage in Malawi: a prospective cohort study
Background Post-tuberculosis lung damage (PTLD) is a recognised consequence of
pulmonary TB (pTB). However, little is known about its prevalence, patterns and associated …
pulmonary TB (pTB). However, little is known about its prevalence, patterns and associated …
Post-tuberculosis lung impairment: systematic review and meta-analysis of spirometry data from 14 621 people
Background A substantial proportion of tuberculosis patients remain with pulmonary
symptoms and reduced physical capacity despite successful treatment. We performed a …
symptoms and reduced physical capacity despite successful treatment. We performed a …
Quantifying the global number of tuberculosis survivors: a modelling study
Background People who survive tuberculosis face clinical and societal consequences after
recovery, including increased risks of recurrent tuberculosis, premature death, reduced lung …
recovery, including increased risks of recurrent tuberculosis, premature death, reduced lung …
Neutrophils in tuberculosis-associated inflammation and lung pathology
CN Muefong, JS Sutherland - Frontiers in immunology, 2020 - frontiersin.org
Protective immunity to Mycobacterium tuberculosis (Mtb)—the causative agent of
tuberculosis (TB)—is not fully understood but involves immune responses within the …
tuberculosis (TB)—is not fully understood but involves immune responses within the …
Tuberculosis related disability: a systematic review and meta-analysis
KA Alene, K Wangdi, S Colquhoun, K Chani, T Islam… - BMC medicine, 2021 - Springer
Background The sustainable development goals aim to improve health for all by 2030. They
incorporate ambitious goals regarding tuberculosis (TB), which may be a significant cause of …
incorporate ambitious goals regarding tuberculosis (TB), which may be a significant cause of …
Host-directed therapies: modulating inflammation to treat tuberculosis
Following infection with Mycobacterium tuberculosis, the causative agent of tuberculosis
(TB), most human hosts are able to contain the infection and avoid progression to active TB …
(TB), most human hosts are able to contain the infection and avoid progression to active TB …
Doxycycline host-directed therapy in human pulmonary tuberculosis
QH Miow, AF Vallejo, Y Wang, JM Hong… - The Journal of …, 2021 - Am Soc Clin Investig
BACKGROUND Matrix metalloproteinases (MMPs) are key regulators of tissue destruction in
tuberculosis (TB) and may be targets for host-directed therapy. We conducted a phase II …
tuberculosis (TB) and may be targets for host-directed therapy. We conducted a phase II …