Alzheimer's disease (AD) is a progressive neurodegenerative disorder; it is the most
common cause of dementia and has no treatment. It is characterized by two pathological …

Ovarian hormones, particularly 17β-estradiol, are involved in numerous neurophysiological
and neurochemical processes, including those subserving cognitive function. Estradiol plays …

Nuclear receptors are classically defined as ligand-activated transcription factors that
regulate key functions in reproduction, development, and physiology. Humans have 48 …

The brain-specific enzyme CYP46A1 controls cholesterol turnover by converting cholesterol
into 24 S-hydroxycholesterol (24OH). Dysregulation of brain cholesterol turnover and …

With the increasing appreciation for sex as a biological variable and the inclusion of female
mice in research, it is important to understand the influence of the estrous cycle on …

Sex differences are present in brain morphology, sex hormones, aging processes and
immune responses. These differences need to be considered for proper modelling of …

Brain-age can be inferred from structural neuroimaging and compared to chronological age
(brain-age delta) as a marker of biological brain aging. Accelerated aging has been found in …

Global populations are increasingly consuming diets high in saturated fats and refined
carbohydrates, and such diets have been well-associated with heightened inflammation and …

Mitochondrial dysfunction and oxidative stress play important roles in the
neuropathogenesis of Parkinson's disease (PD). Epimedin B, the second highest active …

While combinations of pesticides better represent actual conditions within aquatic
ecosystems, the specific toxic effects of these combinations have not been determined yet …