Significance and limitations of the use of next-generation sequencing technologies for detecting mutational signatures
A Abbasi, LB Alexandrov - DNA repair, 2021 - Elsevier
Next generation sequencing technologies (NGS) have been critical in characterizing the
genomic landscape and untangling the genetic heterogeneity of human cancer. Since its …
genomic landscape and untangling the genetic heterogeneity of human cancer. Since its …
Introduction of WT-TP53 into pancreatic cancer cells alters sensitivity to chemotherapeutic drugs, targeted therapeutics and nutraceuticals
SL Abrams, K Lertpiriyapong, LV Yang… - Advances in biological …, 2018 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic malignancy
and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five …
and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five …
The mutREAD method detects mutational signatures from low quantities of cancer DNA
Mutational processes acting on cancer genomes can be traced by investigating mutational
signatures. Because high sequencing costs limit current studies to small numbers of good …
signatures. Because high sequencing costs limit current studies to small numbers of good …
Restriction site associated DNA sequencing for tumour mutation burden estimation and mutation signature analysis
CF McGuinness, MA Black, AK Dunbier - Cancer Medicine, 2023 - Wiley Online Library
Background Genome‐wide measures of genetic disruption such as tumour mutation burden
(TMB) and mutation signatures are emerging as useful biomarkers to stratify patients for …
(TMB) and mutation signatures are emerging as useful biomarkers to stratify patients for …
Effects of the MDM-2 inhibitor Nutlin-3a on PDAC cells containing and lacking WT-TP53 on sensitivity to chemotherapy, signal transduction inhibitors and …
S Candido, SL Abrams, LS Steelman… - Advances in biological …, 2019 - Elsevier
Mutations at the TP53 gene are readily detected (approximately 50–75%) in pancreatic
ductal adenocarcinoma (PDAC) patients. TP53 was previously thought to be a difficult target …
ductal adenocarcinoma (PDAC) patients. TP53 was previously thought to be a difficult target …
Does biology determine survival in pancreatic cancer?
SG Barreto - Future Oncology, 2020 - Taylor & Francis
A recent publication in JAMA Surgery by Jones et al.[1] based on a secondary analysis of
the ESPAC-4 data presented an interesting observation. While local recurrences following …
the ESPAC-4 data presented an interesting observation. While local recurrences following …
Down‐regulation of metabolic pathways could offset the poor prognosis conferred by co‐existent diabetes mellitus in pancreatic (head) adenocarcinoma
N Gardi, M Ketkar, RA McKinnon… - ANZ Journal of …, 2021 - Wiley Online Library
Background Pancreatic ductal adenocarcinoma (PDAC) patients with diabetes mellitus (DM)
have poor overall survival. Underlying mechanisms have not been fully clarified. This …
have poor overall survival. Underlying mechanisms have not been fully clarified. This …
[PDF][PDF] Tumour mutation burden in oestrogen receptor positive breast cancer
CF McGuinness - 2022 - ourarchive.otago.ac.nz
Immune checkpoint blockade (ICB) is a cancer therapy that is based on promoting an
antitumour immune response. Tumour mutation burden (TMB) is an effective biomarker for …
antitumour immune response. Tumour mutation burden (TMB) is an effective biomarker for …
Oligonucleotide adapters and method
R Fitzgerald, K Nowicki-osuch… - US Patent App. 17/999,619, 2024 - Google Patents
The invention relates to a method of preparing a nucleic acid library from a sample
comprising high molecular weight DNA (HMW DNA), preferably genomic DNA, comprising …
comprising high molecular weight DNA (HMW DNA), preferably genomic DNA, comprising …
Analyses de variations génomiques liées à la biogéographie des picoalgues Mamiellales
J Leconte - 2020 - theses.hal.science
Les Mamiellales sont un ordre d'algues vertes unicellulaires cosmopolites comprenant des
espèces d'importance écologique telles que Bathycoccus, Micromonas ou encore …
espèces d'importance écologique telles que Bathycoccus, Micromonas ou encore …