Significance and limitations of the use of next-generation sequencing technologies for detecting mutational signatures

A Abbasi, LB Alexandrov - DNA repair, 2021 - Elsevier
Next generation sequencing technologies (NGS) have been critical in characterizing the
genomic landscape and untangling the genetic heterogeneity of human cancer. Since its …

Introduction of WT-TP53 into pancreatic cancer cells alters sensitivity to chemotherapeutic drugs, targeted therapeutics and nutraceuticals

SL Abrams, K Lertpiriyapong, LV Yang… - Advances in biological …, 2018 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic malignancy
and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five …

The mutREAD method detects mutational signatures from low quantities of cancer DNA

J Perner, S Abbas, K Nowicki-Osuch… - Nature …, 2020 - nature.com
Mutational processes acting on cancer genomes can be traced by investigating mutational
signatures. Because high sequencing costs limit current studies to small numbers of good …

Restriction site associated DNA sequencing for tumour mutation burden estimation and mutation signature analysis

CF McGuinness, MA Black, AK Dunbier - Cancer Medicine, 2023 - Wiley Online Library
Background Genome‐wide measures of genetic disruption such as tumour mutation burden
(TMB) and mutation signatures are emerging as useful biomarkers to stratify patients for …

Effects of the MDM-2 inhibitor Nutlin-3a on PDAC cells containing and lacking WT-TP53 on sensitivity to chemotherapy, signal transduction inhibitors and …

S Candido, SL Abrams, LS Steelman… - Advances in biological …, 2019 - Elsevier
Mutations at the TP53 gene are readily detected (approximately 50–75%) in pancreatic
ductal adenocarcinoma (PDAC) patients. TP53 was previously thought to be a difficult target …

Does biology determine survival in pancreatic cancer?

SG Barreto - Future Oncology, 2020 - Taylor & Francis
A recent publication in JAMA Surgery by Jones et al.[1] based on a secondary analysis of
the ESPAC-4 data presented an interesting observation. While local recurrences following …

Down‐regulation of metabolic pathways could offset the poor prognosis conferred by co‐existent diabetes mellitus in pancreatic (head) adenocarcinoma

N Gardi, M Ketkar, RA McKinnon… - ANZ Journal of …, 2021 - Wiley Online Library
Background Pancreatic ductal adenocarcinoma (PDAC) patients with diabetes mellitus (DM)
have poor overall survival. Underlying mechanisms have not been fully clarified. This …

[PDF][PDF] Tumour mutation burden in oestrogen receptor positive breast cancer

CF McGuinness - 2022 - ourarchive.otago.ac.nz
Immune checkpoint blockade (ICB) is a cancer therapy that is based on promoting an
antitumour immune response. Tumour mutation burden (TMB) is an effective biomarker for …

Oligonucleotide adapters and method

R Fitzgerald, K Nowicki-osuch… - US Patent App. 17/999,619, 2024 - Google Patents
The invention relates to a method of preparing a nucleic acid library from a sample
comprising high molecular weight DNA (HMW DNA), preferably genomic DNA, comprising …

Analyses de variations génomiques liées à la biogéographie des picoalgues Mamiellales

J Leconte - 2020 - theses.hal.science
Les Mamiellales sont un ordre d'algues vertes unicellulaires cosmopolites comprenant des
espèces d'importance écologique telles que Bathycoccus, Micromonas ou encore …